Prenatal phthalate biomarker concentrations and performance on the Bayley Scales of Infant Development-II in a population of young urban children.
Prenatal phthalate biomarker concentrations and performance on the Bayley Scales of Infant Development-II in a population of young urban children.
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DOI：
10.1016/j.envres.2016.09.021
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发表时间：
2017-01
影响因子：
8.3
通讯作者：
Wolff, Mary S.
中科院分区：
文献类型：
--
作者：
Doherty, Brett T.;Engel, Stephanie M.;Buckley, Jessie P.;Silva, Manori J.;Calafat, Antonia M.;Wolff, Mary S.
有证据表明，产前邻苯二甲酸酯暴露可能会对神经发育产生影响。我们的目的是调查一组城市儿童的产前邻苯二甲酸酯暴露和认知发育。我们从1998年到2002年在纽约市招募了孕妇，并测量了妊娠晚期尿液中9种邻苯二甲酸酯代谢物的浓度。我们管理的神经发育筛查工具，婴儿发育的贝利量表II（BSID-II），返回约24个月的随访儿童（n=276）。我们估计了母体尿液中邻苯二甲酸酯代谢物浓度与BSID-II指数（智力发育指数（MDI）、精神发育指数（PDI））之间的相关性。我们没有观察到邻苯二甲酸酯代谢物浓度和性能之间的MDI或PDI的男孩和女孩合并。然而，我们确实观察到了性别效应测量修改的证据。我们观察到代谢物浓度与女孩的MDI和PDI评分之间存在几种负相关性，表明多种代谢物的表现较差，估计肌酐标准化代谢物浓度每增加1/n单位，评分降低2-3分。相反，我们在男孩中观察到多个弱阳性关联，相当于代谢物浓度每增加1 ln单位，评分增加1-2分。最强的相关性为代谢物邻苯二甲酸单正丁酯、邻苯二甲酸单异丁酯、邻苯二甲酸单苄酯和邻苯二甲酸单（3-羧基丙基）酯（MCPP）。母亲尿中MCPP和邻苯二甲酸酯类代谢物浓度较高的女孩在BSID-II上的MDI评分较低。这些相同的生物标志物浓度通常与男孩的分数提高有关。我们在PDI上观察到MnBP、MCPP和MBzP的类似结果。鉴于育龄妇女中邻苯二甲酸酯暴露的普遍性，潜在神经毒性的影响需要进一步研究。
Evidence suggests prenatal phthalate exposures may have neurodevelopmental consequences. Our objective was to investigate prenatal exposure to phthalates and cognitive development in a cohort of young urban children. We recruited pregnant women in New York City from 1998 to 2002 and measured concentrations of nine phthalate metabolites in urine collected in late pregnancy. We administered a neurodevelopmental screening instrument, the Bayley Scales of Infant Development II (BSID-II), to children who returned for follow-up at approximately 24 months (n=276). We estimated associations between phthalate metabolite concentrations in maternal urine and BSID-II indices (Mental Development Index (MDI), Psychomotor Development Index (PDI)). We observed no associations between phthalate metabolite concentrations and performance on the MDI or PDI in boys and girls combined. We did, however, observe evidence of effect measure modification by sex. We observed several negative associations between metabolite concentrations and both MDI and PDI scores among girls, suggesting poorer performance across multiple metabolites, with estimates equal to a 2-3 point decrease in score per ln-unit increase in creatinine-standardized metabolite concentration. Conversely, we observed multiple weakly positive associations among boys, equal to a 1-2 point increase in score per ln-unit increase in metabolite concentration. The strongest associations were for the metabolites mono-n-butyl phthalate, monoisobutyl phthalate, monobenzyl phthalate, and mono(3-carboxylpropyl) phthalate (MCPP). Girls of mothers with higher urinary concentrations of MCPP and metabolites of dibutyl phthalates had lower MDI scores on the BSID-II. These same biomarker concentrations were often associated with improved scores among boys. We observed similar results for MnBP, MCPP, and MBzP on the PDI. Given the prevalence of phthalate exposures in reproductive aged women, the implications of potential neurotoxicity warrant further investigation.
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影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
影响因子：
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10.1016/j.beem.2004.03.012
发表时间：
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影响因子：
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作者：
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影响因子：
7.4
作者：
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作者：
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