Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta.
Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta.
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DOI：
10.3390/ijms150916153
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发表时间：
2014-09-12
影响因子：
5.6
通讯作者：
Adamo KB
中科院分区：
文献类型：
--
作者：
Brett KE;Ferraro ZM;Yockell-Lelievre J;Gruslin A;Adamo KB
适当的子宫内生长对于后代的发育至关重要，也是长期健康的关键贡献者。胎儿的生长很大程度上取决于母体循环中营养物质的可用性以及这些营养物质通过胎盘输送到胎儿循环的能力。跨胎盘梯度的底物通量取决于营养特异性转运蛋白的可及性和活性。这些转运蛋白的表达和活性的变化与胎儿生长受限和过度生长有关，并且可能代表胎儿生长速率试图与母体循环中营养物质的可用性相匹配的控制机制。本综述概述了胎盘营养物转运，重点是常量营养物转运蛋白。它强调了这些转运蛋白的表达和活性的变化与常见妊娠病理相关，包括宫内生长受限、巨大儿、糖尿病和肥胖，以及母亲饮食的潜在影响。讨论了连接母体营养可用性和胎盘营养运输的分子信号传导途径。考虑性别二态性如何影响胎儿生长策略以及胎盘对宫内环境改变的反应。该领域的进一步知识可能是制定有针对性的干预措施以帮助优化胎儿生长的第一步。
Appropriate in utero growth is essential for offspring development and is a critical contributor to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal circulation and the ability of these nutrients to be transported into fetal circulation via the placenta. Substrate flux across placental gradients is dependent on the accessibility and activity of nutrient-specific transporters. Changes in the expression and activity of these transporters is implicated in cases of restricted and excessive fetal growth, and may represent a control mechanism by which fetal growth rate attempts to match availability of nutrients in maternal circulation. This review provides an overview of placenta nutrient transport with an emphasis on macro-nutrient transporters. It highlights the changes in expression and activity of these transporters associated with common pregnancy pathologies, including intrauterine growth restriction, macrosomia, diabetes and obesity, as well as the potential impact of maternal diet. Molecular signaling pathways linking maternal nutrient availability and placenta nutrient transport are discussed. How sexual dimorphism affects fetal growth strategies and the placenta’s response to an altered intrauterine environment is considered. Further knowledge in this area may be the first step in the development of targeted interventions to help optimize fetal growth.
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影响因子：
3.8
作者：
Brass, E.;Hanson, E.;O'Tierney-Ginn, P. F.
通讯作者：
O'Tierney-Ginn, P. F.
影响因子：
3.6
作者：
Dube, Evemie;Ethier-Chiasson, Maude;Lafond, Julie
通讯作者：
Lafond, Julie
影响因子：
5.5
作者：
Coan, P. M.;Vaughan, O. R.;Fowden, A. L.
通讯作者：
Fowden, A. L.
影响因子：
2.5
作者：
CLANDININ, MT;CHAPPELL, JE;CHANCE, GW
通讯作者：
CHANCE, GW
DOI：
10.3109/14767058.2011.638953
发表时间：
2012-05-01
影响因子：
1.8
作者：
Ferraro, Z. M.;Barrowman, N.;Adamo, K. B.
通讯作者：
Adamo, K. B.