Placental oleic acid uptake is lower in male offspring of obese women.
Placental oleic acid uptake is lower in male offspring of obese women.
复制标题
DOI：
10.1016/j.placenta.2013.03.009
复制
发表时间：
2013-06
期刊：
影响因子：
3.8
通讯作者：
O'Tierney-Ginn, P. F.
中科院分区：
文献类型：
--
作者：
Brass, E.;Hanson, E.;O'Tierney-Ginn, P. F.
胎儿依赖于胎盘供应长链多不饱和脂肪酸(LCPUFA)，这是胎儿生长发育所必需的。以前的研究表明，孕妇的高体重指数(BMI)会抑制胎儿LCPUFA的分娩，而且男性在发育过程中对脂肪酸的需求比女性更大。我们假设男性胎盘脂肪酸摄取对母亲BMI比女性更敏感。足月胎盘样本来自健康剖宫产妇女(n=38)。检测胎盘脂肪酸转运体和结合蛋白基因的表达及对油酸(OA)、花生四烯酸(AA)和二十二碳六酸(DHA)的摄取。用双因素方差分析评估胎儿性别和母亲超重/肥胖(BMI>；26 kg/m2)的影响。与正常体重指数女性相比，肥胖男性子代胎盘脂肪酸摄取量降低43%，而女性子代胎盘脂肪酸摄取量增加73%(p<；0.05)。胎儿性别与母亲体重指数的交互作用对骨钙素(OA)(P=0.002.0 1)和氨基酸摄取(P=0.0 1)均有显著影响。DHA摄取不受胎儿性别或母亲肥胖的影响。肥胖母亲的男性子代胎盘脂肪酸转运蛋白CD36和结合蛋白FABP5基因表达水平较低，而女性胎盘脂肪酸转运体CD36和结合蛋白FABP5基因表达水平不受体重指数的影响。母亲肥胖和胎儿性别显著影响胎盘对油酸和花生四烯酸的摄取。男性和女性胎儿的胎盘脂肪酸摄取对母亲的BMI很敏感，但当暴露在母亲肥胖的环境中时，男性可能对不饱和脂肪酸OA的获取不足。
The fetus is dependent on the placenta for its supply of long chain polyunsaturated fatty acids (LCPUFA), which are essential in fetal growth and development. Previous work suggests that high maternal body mass index (BMI) inhibits fetal LCPUFA delivery and males have greater fatty acid requirements than females during development. We hypothesized that male placental fatty acid uptake would be more sensitive to maternal BMI compared to females. Term placental samples were collected from healthy women receiving Cesarean section (n=38). Placental fatty acid transporter and binding protein gene expression and uptake of oleic acid (OA), arachidonic acid, (AA) and docosahexanoic acid (DHA) was measured. Two-way ANOVA was used to assess the effects of fetal sex and maternal overweight/obesity (BMI>26 kg/m2). Placental fatty acid uptake of OA was 43% lower in male offspring and 73% higher in female offspring of obese compared to normal BMI women (p<0.05). The interaction between fetal sex and maternal BMI had a significant effect on both OA (P=0.002) and AA uptake (P=0.01). DHA uptake was not affected by fetal sex or maternal obesity. Placental fatty acid transporter CD36 and binding protein FABP5 gene expression levels were lower in male offspring of obese mothers but were not affected by BMI among females. Maternal obesity and fetal sex significantly affect the placental uptake of oleate and arachidonate. Placental fatty acid uptake in both male and female fetuses is sensitive to maternal BMI, but males may have inadequate acquisition of the unsaturated fatty acid OA, when exposed to maternal obesity.
登录
查看更多内容
影响因子：
3.7
作者：
Mishima T;Miner JH;Morizane M;Stahl A;Sadovsky Y
通讯作者：
Sadovsky Y
影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
影响因子：
4.3
作者：
Campbell, FM;Gordon, MJ;DuttaRoy, AK
通讯作者：
DuttaRoy, AK
DOI：
10.1073/pnas.1000440107
发表时间：
2010-03-23
影响因子：
11.1
作者：
Mao, Jiude;Zhang, Xia;Rosenfeld, Cheryl S.
通讯作者：
Rosenfeld, Cheryl S.
影响因子：
3.8
作者：
Roberts, K. A.;Riley, S. C.;Denison, F. C.
通讯作者：
Denison, F. C.