Pre- and post-natal macronutrient supplementation for HIV-positive women in Tanzania: Effects on infant birth weight and HIV transmission.
Pre- and post-natal macronutrient supplementation for HIV-positive women in Tanzania: Effects on infant birth weight and HIV transmission.
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DOI：
10.1371/journal.pone.0201038
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
DarDar-2 Study Team
中科院分区：
文献类型：
--
作者：
Magohe A;Mackenzie T;Kimario J;Lukmanji Z;Hendricks K;Koethe J;Neke NM;Tvaroha S;Connor R;Waddell R;Maro I;Matee M;Pallangyo K;Bakari M;von Reyn CF;DarDar-2 Study Team
To determine if a protein-calorie supplement (PCS) plus a micronutrient supplement (MNS) improves outcomes for HIV-infected lactating women and their infants. Randomized, controlled trial. Dar es Salaam, Tanzania Pregnant HIV-infected women enrolled in PMTCT programs who intended to breastfeed for 6 months. Randomization 1:1 to administration of a PCS plus MNS versus MNS alone among 96 eligible women beginning in the third trimester and continuing for 6 months of breast-feeding. Primary: infant weight at 3 months. Secondary: maternal BMI at 6 months. PCS resulted in significant increases in daily energy intake compared to MNS at all time points (range of differences: +388–719 Kcal); and increases in daily protein intake (range of differences: +22–33 gm). Infant birth weight (excluding twins) was higher in the PCS than MNS groups: 3.30 kg vs 3.04 kg (p = 0.04). Infant weight at 3 months did not differ between PCS and MNS groups: 5.63 kg vs 5.99 kg (p = 0.07). Maternal BMI at 6 months did not differ between PCS and MNS groups: 24.3 vs 23.8 kg/m2 (p = 0.68). HIV transmission occurred in 0 infants in the PCS group vs 4 in the MNS group (p = 0.03). In comparison to MNS the PCS + MNS intervention was well tolerated, increased maternal energy and protein intake, and increased infant birth weight, but not weight at 3 months or maternal BMI at 6 months. Reduced infant HIV transmission in the PCS + MNS group was observed. Clinical Trials.Gov NCT01461863.
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影响因子：
1.8
作者：
Lukmanji, Zohra;Hertzmark, Ellen;Fawzi, Wafaie W.
通讯作者：
Fawzi, Wafaie W.
DOI：
10.1097/qai.0000000000000352
发表时间：
2014-12-05
影响因子：
3.6
作者：
Kim, Faith;Neke, Nyasule M.;von Reyn, C. Fordham
通讯作者：
von Reyn, C. Fordham
DOI：
10.1097/qai.0b013e3182797363
发表时间：
2013-02-01
影响因子：
3.6
作者：
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通讯作者：
Kadiyala, Suneetha
影响因子：
158.5
作者：
Fawzi, Wafaie W.;Msamanga, Gernard I.;Spiegelman, Donna
通讯作者：
Spiegelman, Donna
影响因子：
158.5
作者：
McIntire, DD;Bloom, SL;Leveno, KJ
通讯作者：
Leveno, KJ