Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.
Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.
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DOI：
10.1038/ncomms2461
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
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人类情绪和社会行为背后的神经化学变化在很大程度上是未知的。在这里，我们报告了在人类杏仁核中测量的两种下丘脑神经肽，下丘脑分泌素-1 （Hcrt-1）和黑色素浓缩激素（MCH）水平的变化。我们发现，Hcrt-1水平在积极情绪、社会互动和愤怒时达到最高水平，这些行为会导致嗜睡症患者发作。相比之下，MCH水平在社交互动中最低，但在进食后增加。这两种肽在术后疼痛期间都处于最低水平，尽管唤起水平很高。MCH水平在睡眠开始时增加，与睡眠诱导的作用一致，而Hcrt-1水平在清醒开始时增加，与清醒诱导的作用一致。人类体内这两种肽的水平不仅与觉醒有关，而且与特定的情绪和状态转变有关。其他的唤醒系统可能也有类似的情感专门化。
The neurochemical changes underlying human emotions and social behavior are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 (Hcrt-1) and melanin concentrating hormone (MCH), measured in the human amygdala. We show that Hcrt-1 levels are maximal during positive emotion, social interaction, and anger, behaviors that induce cataplexy in human narcoleptics. In contrast, MCH levels are minimal during social interaction, but are increased after eating. Both peptides are at minimal levels during periods of postoperative pain despite high levels of arousal. MCH levels increase at sleep onset, consistent with a role in sleep induction, whereas Hcrt-1 levels increase at wake onset, consistent with a role in wake induction. Levels of these two peptides in humans are not simply linked to arousal, but rather to specific emotions and state transitions. Other arousal systems may be similarly emotionally specialized.
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