Circuit mechanisms and computational models of REM sleep.
Circuit mechanisms and computational models of REM sleep.
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DOI：
10.1016/j.neures.2018.08.003
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发表时间：
2019-03
影响因子：
2.9
通讯作者：
Sakata S
中科院分区：
文献类型：
--
作者：
Héricé C;Patel AA;Sakata S
REM睡眠是在1950年代被发现的。许多下丘脑和脑干区域被发现有助于快速眼动睡眠。本文综述了REM睡眠调节回路的最新研究进展。快速眼动睡眠调节的计算模型的简要概述。对未来研究中存在的问题进行了讨论。快速眼动（REM）睡眠或异相睡眠是一种难以捉摸的行为状态。自20世纪50年代发现以来，我们对REM睡眠调节的神经解剖学、神经递质和神经肽的认识随着新技术的发展而不断发展。虽然最初发现脑桥负责REM睡眠，但后来发现下丘脑、中脑、脑桥和髓质中的许多成分也有助于REM睡眠。在这篇综述中，我们首先提供了一个最新的概述REM睡眠调节回路在脑干和下丘脑的神经解剖学，神经生理学和增益和功能丧失的研究总结实验证据。第二，因为定量的方法是必不可少的了解REM睡眠调节电路的复杂性，因为数学模型提供了宝贵的见解REM睡眠的发生和维持的动力学基础，我们总结了计算研究的睡眠-觉醒周期，重点对REM睡眠调节。最后，我们讨论了未来研究的突出问题。
REM sleep was discovered in the 1950s. Many hypothalamic and brainstem areas have been found to contribute to REM sleep. An up-to-date picture of REM-sleep-regulating circuits is reviewed. A brief overview of computational models for REM sleep regulation is provided. Outstanding issues for future studies are discussed. Rapid eye movement (REM) sleep or paradoxical sleep is an elusive behavioral state. Since its discovery in the 1950s, our knowledge of the neuroanatomy, neurotransmitters and neuropeptides underlying REM sleep regulation has continually evolved in parallel with the development of novel technologies. Although the pons was initially discovered to be responsible for REM sleep, it has since been revealed that many components in the hypothalamus, midbrain, pons, and medulla also contribute to REM sleep. In this review, we first provide an up-to-date overview of REM sleep-regulating circuits in the brainstem and hypothalamus by summarizing experimental evidence from neuroanatomical, neurophysiological and gain- and loss-of-function studies. Second, because quantitative approaches are essential for understanding the complexity of REM sleep-regulating circuits and because mathematical models have provided valuable insights into the dynamics underlying REM sleep genesis and maintenance, we summarize computational studies of the sleep-wake cycle, with an emphasis on REM sleep regulation. Finally, we discuss outstanding issues for future studies.
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影响因子：
2.1
作者：
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通讯作者：
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