Dendritic Cells Transduced with Single Immunoglobulin IL-1-Related Receptor Exhibit Immature Properties and Prolong Islet Allograft Survival.
Dendritic Cells Transduced with Single Immunoglobulin IL-1-Related Receptor Exhibit Immature Properties and Prolong Islet Allograft Survival.
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用单一免疫球蛋白 IL-1 相关受体转导的树突状细胞表现出不成熟的特性并延长胰岛同种异体移植物的存活
DOI：
10.3389/fimmu.2017.01671
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发表时间：
2017
影响因子：
7.3
通讯作者：
Ma Y
中科院分区：
文献类型：
--
作者：
Xue Z;Zhang X;Chen M;Lu X;Deng R;Ma Y
toll样受体-白细胞介素1受体信号通路[TLR/IL-1R (TIR)]超家族成员介导树突状细胞（dc）成熟并在移植器官中启动免疫反应。在本研究中，我们假设TIR8，也被称为单免疫球蛋白il -1相关受体（SIGIRR）分子，抑制dc成熟并诱导移植器官的免疫耐受。用重组腺病毒Ad5F35诱导树突状细胞高表达SIGIRR (DC-SIGIRR)，在胰岛移植前注射给小鼠受体。结果表明，SIGIRR转导的树突状细胞具有较低的主要组织相容性和共刺激分子表达和较强的体外吞噬能力。数据显示，DC-SIGIRR治疗的受者具有令人满意的胰岛异体移植功能和较长的存活时间，体内脾脏和引流淋巴结Treg升高，Th17减少。因此，SIGIRR基因修饰可以抑制DC的激活和成熟，影响T细胞亚群的分化，保护同种异体移植物的生物学功能，延长移植物的存活时间。
Members of toll-like receptor-interleukin 1 receptor signaling [TLR/IL-1R (TIR)] superfamily mediate maturation of dendritic cells (DCs) and launch immune response in transplanted organs. In this study, we hypothesized that TIR8, also known as single immunoglobulin IL-1-related receptor (SIGIRR) molecule, refrain DCs from maturation and induce immune tolerance of transplanted organ. DCs were transduced with the recombinant adenovirus Ad5F35 to highly express SIGIRR (DC-SIGIRR), then injected to murine recipient before islet transplantation. It revealed that DCs transduced with SIGIRR had low expression of major histocompatibility and costimulatory molecules along with strong phagocytic ability in vitro assay. The data demonstrated that recipients treated with DC-SIGIRR had satisfying islet allograft function and long survival times, with an increase of Treg and reduction of Th17 in both spleen and draining lymph nodes in vivo. Therefore, genetic modification of SIGIRR inhibits DC activation and maturation, affects differentiation of T cell subsets, protects allograft biological function, and prolongs graft survival.
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影响因子：
168.9
作者：
Wekerle, Thomas;Segev, Dorry;Oberbauer, Rainer
通讯作者：
Oberbauer, Rainer
影响因子：
1.2
作者：
Zmuda, Erik J.;Powell, Catherine A.;Hai, Tsonwin
通讯作者：
Hai, Tsonwin
DOI：
10.1152/ajpendo.90617.2008
发表时间：
2008-12-01
影响因子：
5.1
作者：
Andrikopoulos, Sofianos;Blair, Amy R.;Proietto, Joseph
通讯作者：
Proietto, Joseph
影响因子：
15.9
作者：
Goldstein, DR;Tesar, BM;Lakkis, FG
通讯作者：
Lakkis, FG
影响因子：
30.5
作者：
Wald, D;Qin, JZ;Li, XX
通讯作者：
Li, XX