A review of neuroimaging findings in repetitive brain trauma.
A review of neuroimaging findings in repetitive brain trauma.
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DOI：
10.1111/bpa.12249
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Shenton ME
中科院分区：
文献类型：
--
作者：
Koerte IK;Lin AP;Willems A;Muehlmann M;Hufschmidt J;Coleman MJ;Green I;Liao H;Tate DF;Wilde EA;Pasternak O;Bouix S;Rathi Y;Bigler ED;Stern RA;Shenton ME
慢性创伤性脑病（CTE）是一种在死后证实的神经退行性疾病。风险最高的是参加接触性运动的职业运动员和暴露于重复爆炸事件的军事人员。迄今为止，所有神经病理学证实的CTE病例都有重复头部撞击的病史。这表明，重复的头部撞击可能是必要的致病级联的启动，在某些情况下，导致CTE。重要的是，虽然所有CTE似乎都是由重复性脑创伤引起的，但并非所有重复性脑创伤都会导致CTE。磁共振成像对于更好地了解重复性脑外伤的潜在机制具有巨大的潜力。在这篇综述中，我们提供了一个先进的成像技术，目前用于调查大脑异常的概述。我们还提供了一个概述的神经影像学研究结果暴露于反复头部撞击在急性/亚急性和慢性阶段的损伤，并在更多的神经退行性阶段的损伤，以及在军事人员暴露于反复头部撞击。最后，我们讨论了未来的研究方向，这可能会导致更好地理解那些从重复性脑创伤中恢复的人与那些继续发展CTE的人之间的潜在机制。
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease confirmed at post-mortem. Those at highest risk are professional athletes who participate in contact sports and military personnel who are exposed to repetitive blast events. All neuropathologically-confirmed CTE cases, to date, have had a history of repetitive head impacts. This suggests that repetitive head impacts may be necessary for the initiation of the pathogenetic cascade that, in some cases, leads to CTE. Importantly, while all CTE appears to result from repetitive brain trauma, not all repetitive brain trauma results in CTE. Magnetic resonance imaging has great potential for understanding better the underlying mechanisms of repetitive brain trauma. In this review we provide an overview of advanced imaging techniques currently used to investigate brain anomalies. We also provide an overview of neuroimaging findings in those exposed to repetitive head impacts in the acute/subacute and chronic phase of injury and in more neurodegenerative phases of injury, as well as in military personnel exposed to repetitive head impacts. Finally, we discuss future directions for research that will likely lead to a better understanding of the underlying mechanisms separating those who recover from repetitive brain trauma versus those who go on to develop CTE.
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影响因子：
2.9
作者：
Bigler ED
通讯作者：
Bigler ED
影响因子：
3.2
作者：
Baugh, Christine M.;Stamm, Julie M.;Stern, Robert A.
通讯作者：
Stern, Robert A.
影响因子：
3.7
作者：
Bazarian JJ;Zhu T;Zhong J;Janigro D;Rozen E;Roberts A;Javien H;Merchant-Borna K;Abar B;Blackman EG
通讯作者：
Blackman EG
影响因子：
3.7
作者：
Bouix S;Pasternak O;Rathi Y;Pelavin PE;Zafonte R;Shenton ME
通讯作者：
Shenton ME
DOI：
10.1016/j.carj.2009.09.002
发表时间：
2010-02-01
影响因子：
3.1
作者：
Aviv, Richard I.;Tomlinson, George;Valentine, Alan
通讯作者：
Valentine, Alan