Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy.

Estrogen regulation of placental angiogenesis and fetal ovarian development during primate pregnancy.
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DOI:
10.1387/ijdb.082758ea
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发表时间:
2010
期刊:
The International journal of developmental biology
影响因子:
--
通讯作者:
Pepe GJ
Pepe GJ
中科院分区:
其他
文献类型:
--
作者:
Albrecht ED;Pepe GJ

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在人类和非人灵长类动物怀孕期间,绒毛胎盘内建立了广泛的血管网络,以支持胎儿的生长,胎儿卵巢内的卵泡发育,为成年后的生殖功能提供了卵母细胞池。这两个重要的发育事件的发生与胎盘雌激素的产生和水平的逐渐增加有关。该综述将描述胎盘血管形成和胎儿卵泡成熟所需的发育过程以及最近的研究表明雌激素在调节这些事件中起着重要作用。
During human and nonhuman primate pregnancy, an extensive blood vessel network is established within the villous placenta to support fetal growth and follicles develop within the fetal ovary to provide a pool of oocytes for reproductive function in adulthood. These two important developmental events occur in association with a progressive increase in placental estrogen production and levels. This review will describe the developmental processes required for placental vascularization and fetal follicular maturation and recent studies which show that estrogen has an important role in regulating these events.
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