circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations.
circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations.
复制标题
DOI：
10.1093/nar/gkad949
复制
发表时间：
2024-01-05
影响因子：
14.9
通讯作者：
Jiang, Tao
中科院分区：
文献类型：
--
作者：
Sun, Zhi-Yan;Yang, Chang-Lin;Huang, Li-Jie;Mo, Zong-Chao;Zhang, Ke-Nan;Fan, Wen-Hua;Wang, Kuan-Yu;Wu, Fan;Wang, Ji-Guang;Meng, Fan-Lin;Zhao, Zheng;Jiang, Tao
circRNADisease v2.0 是一个增强且可靠的数据库，提供经过实验验证的环状 RNA (circRNA) 与各种疾病之间的关系。可通过http://cgga.org.cn/circRNADisease/或http://cgga.org.cn:9091/circRNADisease/访问。该数据库目前包含多个物种的 6998 个 circRNA 疾病条目，与之前的版本相比增加了 19.77 倍。这种扩展包括 circRNA 数量（从 330 种增加到 4246 种）、疾病类型（从 48 种增加到 330 种）和覆盖物种（从人类增加到 12 种）的大幅增加。此外，数据库中引入了一个新部分，收集有关circRNA相关因子（基因、蛋白质和microRNA）、分子机制（分子途径）、生物学功能（增殖、迁移、侵袭等）、肿瘤和/或细胞系和/或患者来源的异种移植物（PDX）详细信息以及疾病预后证据的信息。此外，我们还确定了 30 种 TCGA 癌症类型中突变与 circRNA 之间的 7 159 865 种关系。由于显着的增强和广泛的数据扩展，circRNADisease 2.0 数据库已成为临床实践和基础研究的宝贵资产。它使研究人员能够更全面地了解 circRNA 如何影响复杂疾病。
circRNADisease v2.0 is an enhanced and reliable database that offers experimentally verified relationships between circular RNAs (circRNAs) and various diseases. It is accessible at http://cgga.org.cn/circRNADisease/ or http://cgga.org.cn:9091/circRNADisease/. The database currently includes 6998 circRNA-disease entries across multiple species, representing a remarkable 19.77-fold increase compared to the previous version. This expansion consists of a substantial rise in the number of circRNAs (from 330 to 4246), types of diseases (from 48 to 330) and covered species (from human only to 12 species). Furthermore, a new section has been introduced in the database, which collects information on circRNA-associated factors (genes, proteins and microRNAs), molecular mechanisms (molecular pathways), biological functions (proliferation, migration, invasion, etc.), tumor and/or cell line and/or patient-derived xenograft (PDX) details, and prognostic evidence in diseases. In addition, we identified 7 159 865 relationships between mutations and circRNAs among 30 TCGA cancer types. Due to notable enhancements and extensive data expansions, the circRNADisease 2.0 database has become an invaluable asset for both clinical practice and fundamental research. It enables researchers to develop a more comprehensive understanding of how circRNAs impact complex diseases.
登录
查看更多内容
DOI：
10.1093/bioinformatics/btq033
发表时间：
2010-03-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Quinlan AR;Hall IM
通讯作者：
Hall IM
影响因子：
9
作者：
Li RC;Ke S;Meng FK;Lu J;Zou XJ;He ZG;Wang WF;Fang MH
通讯作者：
Fang MH
DOI：
10.1007/978-981-13-1426-1_6
发表时间：
2018-01-01
期刊：
CIRCULAR RNAS: BIOGENESIS AND FUNCTIONS
影响因子：
--
作者：
Panda, Amaresh Chandra
通讯作者：
Panda, Amaresh Chandra
DOI：
10.1093/database/baq020
发表时间：
2010-08-05
期刊：
Database : the journal of biological databases and curation
影响因子：
--
作者：
Safran M;Dalah I;Alexander J;Rosen N;Iny Stein T;Shmoish M;Nativ N;Bahir I;Doniger T;Krug H;Sirota-Madi A;Olender T;Golan Y;Stelzer G;Harel A;Lancet D
通讯作者：
Lancet D
环状 RNA 编码的致癌 E-钙粘蛋白变体通过激活 EGFR-STAT3 信号传导促进胶质母细胞瘤致瘤性。
影响因子：
21.3
作者：
Gao, Xinya;Xia, Xin;Zhang, Nu
通讯作者：
Zhang, Nu