Olfactory behavior and physiology are disrupted in prion protein knockout mice.
Olfactory behavior and physiology are disrupted in prion protein knockout mice.
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DOI：
10.1038/nn.2238
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发表时间：
2009-01
影响因子：
25
通讯作者：
Firestein, Stuart
中科院分区：
文献类型：
--
作者：
Le Pichon, Claire E.;Valley, Matthew T.;Polymenidou, Magdalini;Chesler, Alexander T.;Sagdullaev, Botir T.;Aguzzi, Adriano;Firestein, Stuart
The prion protein PrPC is infamous for its role in disease, yet its normal physiological function remains unknown. Here we report a novel behavioral phenotype of PrP−/− mice in an odor-guided task. This phenotype is manifest in three PrP knockout lines on different genetic backgrounds, strong evidence it is specific to the lack of PrPC rather than other genetic factors. PrP−/− mice also display altered behavior in a second olfactory task, suggesting the phenotype is olfactory specific. Furthermore, PrPC deficiency affects oscillatory activity in the deep layers of the main olfactory bulb, as well as dendrodendritic synaptic transmission between olfactory bulb granule and mitral cells. Importantly, both the behavioral and electrophysiological alterations found in PrP−/− mice are rescued by transgenic neuronal-specific expression of PrPC. These data suggest a critical role for PrPC in the normal processing of sensory information by the olfactory system.
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