Functional Fcgamma receptor polymorphisms are associated with human allergy.
Functional Fcgamma receptor polymorphisms are associated with human allergy.
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DOI：
10.1371/journal.pone.0089196
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Blumenthal MN
中科院分区：
文献类型：
--
作者：
Wu J;Lin R;Huang J;Guan W;Oetting WS;Sriramarao P;Blumenthal MN
IgG Fc受体（FcγRs）在免疫应答中起重要作用。目前尚不清楚FcγR受体是否在人类哮喘和过敏中发挥作用。本研究旨在探讨FcγR基因（FCGR）功能性单核苷酸多态性（SNPs）与人类哮喘和变态反应的关系。FCGR 2A的功能性SNP（FcγRIIA-131 His>Arg，rs1801274），FCGR2B（FcγRIIB-187 Ile>Thr，rs1050501），FCGR2C（FcγRIIC-13 Gln>Stop，rs10917661），FCGR3A（FcγRIIIA-158 Val>Phe，rs396991）和FCGR 3B变体在包括370名特异性反应阳性、239名特异性反应阴性和169名哮喘阳性受试者的哮喘家族队列中，对FcγRIIIB NA 1和NA 2进行基因分型。使用基于家族的关联检验（FBAT）和年龄和性别校正的logistic回归分析受试者的基因型和表型数据（哮喘、支气管高反应性和特应性）。在基于家族的关联检验（P = 0.00287）和逻辑回归分析（P = 0.0269，OR 0.732，95%CI：0.555-0.965）中，FcγRIIA-131 His>Arg SNP与特应性显著相关。 能够结合人IgG 2的FcγRIIA-131 His（或rs 1801274-A）等位基因对特应性具有保护作用。此外，罕见的FcγRIIB-187 Thr（或rs 1050501-C）等位基因缺陷的受体介导的抑制信号是特应性（P = 0.0031，OR 1.758，95% CI：1.209-2.556）和IgE产生（P<0.001）的风险因素。 然而，活化FcγRIIIA（rs396991）、FcγRIIIB（NA 1和NA 2）和FcγRIIC（rs 10917661）的变体与哮喘、BHR和特应性无关（P>0.05）。FcγRIIA和FcγRIIB功能多态性可能在变态反应的发病机制中起作用。
IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR) are associated with human asthma and allergy. Functional SNPs of FCGR2A (FcγRIIA-131His>Arg, rs1801274), FCGR2B (FcγRIIB-187Ile>Thr, rs1050501), FCGR2C (FcγRIIC-13Gln>Stop, rs10917661), FCGR3A (FcγRIIIA-158Val>Phe, rs396991), and FCGR3B variants (FcγRIIIB NA1 and NA2) were genotyped in an asthma family cohort including 370 atopy positive, 239 atopy negative, and 169 asthma positive subjects. The genotype and phenotype data (asthma, bronchial hyper-responsiveness, and atopy) of subjects were analyzed using family-based association tests (FBAT) and logistic regression adjusted for age and sex. The FcγRIIA-131His>Arg SNP is significantly associated with atopy in a family-based association test (P = 0.00287) and in a logistic regression analysis (P = 0.0269, OR 0.732, 95% CI: 0.555–0.965). The FcγRIIA-131His (or rs1801274-A) allele capable of binding human IgG2 has a protective role against atopy. In addition, the rare FcγRIIB-187Thr (or rs1050501-C) allele defective for the receptor-mediated inhibitory signals is a risk factor for atopy (P = 0.0031, OR 1.758, 95% CI: 1.209–2.556) and IgE production (P<0.001). However, variants of activating FcγRIIIA (rs396991), and FcγRIIIB (NA1 and NA2), and FcγRIIC (rs10917661) are not associated with asthma, BHR, and atopy (P>0.05). FcγRIIA and FcγRIIB functional polymorphisms may have a role in the pathogenesis of allergy.
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影响因子：
15.9
作者：
Boruchov, AM;Heller, G;Young, JW
通讯作者：
Young, JW
影响因子：
2.6
作者：
Diamantopoulos, Panagiotis T.;Kalotychou, Vassiliki;Viniou, Nora-Athina
通讯作者：
Viniou, Nora-Athina
影响因子：
4.4
作者：
Forthal, Donald N.;Landucci, Gary;Montoya, Benjamin
通讯作者：
Montoya, Benjamin
影响因子：
3.6
作者：
Malbec, O;Attal, JP;Daëron, M
通讯作者：
Daëron, M
影响因子：
2.1
作者：
Blangero, J;Williams, JT;Almasy, L
通讯作者：
Almasy, L