Development and homeostasis of the sebaceous gland.
Development and homeostasis of the sebaceous gland.
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DOI：
10.1016/j.semcdb.2012.08.010
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发表时间：
2012-10
影响因子：
7.3
通讯作者：
Horsley V
中科院分区：
文献类型：
--
作者：
Niemann C;Horsley V
表皮附属物，特别是皮脂腺的重要作用直到最近才被认识到。特别地，已经令人信服地表明，皮脂腺的正常发育和维持是皮肤稳态所需的，因为萎缩的皮脂腺和皮脂脂质组成的紊乱导致皮肤的生理屏障和维持的主要缺陷。因此，重要的是要解开控制哺乳动物皮肤中适当的皮脂谱系分化的信号网络，并了解导致严重皮肤疾病的潜在机制，包括腺体的异常增殖和分化，脂质代谢和屏障的缺陷，以及皮脂肿瘤的形成。在过去的几年中，来自操纵皮肤中不同信号通路的转基因和敲除小鼠模型的结果以及对人类皮脂腺衍生细胞系的详细分析为平衡皮脂腺增殖和分化的关键介质提供了新的见解。在这里，我们讨论了我们目前的知识，在体内机制的皮脂腺的发展，维护和疾病，并强调最近的贡献领域的皮脂腺生物学。
The important role of epidermal appendages especially the sebaceous gland has only recently been recognised. In particular, it has been convincingly shown that normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and maintenance of the skin. Consequently, it is important to unravel the signalling network controlling proper sebaceous lineage differentiation in mammalian skin and to understand the underlying mechanisms leading to severe skin diseases, including abnormal proliferation and differentiation of the gland, defects of the lipid metabolism and barrier, as well as sebaceous tumour formation. Over the last years, results from transgenic and knock out mouse models manipulating distinct signalling pathways in the skin as well as the detailed analysis of human sebaceous gland-derived cell lines provided new insights into crucial mediators balancing proliferation and differentiation of the sebaceous gland. Here, we discuss our current knowledge of in vivo mechanisms of sebaceous gland development, maintenance and disorders and highlight recent contributions to the field of sebaceous gland biology.
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