Alpha-melanocyte-stimulating hormone attenuates behavioral effects of corticotropin-releasing factor in isolated guinea pig pups.
Alpha-melanocyte-stimulating hormone attenuates behavioral effects of corticotropin-releasing factor in isolated guinea pig pups.
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α-黑素细胞刺激激素减弱促肾上腺皮质激素释放因子对离体豚鼠幼崽的行为影响。
DOI：
10.1002/dev.20379
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发表时间：
2009
影响因子：
2.2
通讯作者：
Hennessy,MichaelB
中科院分区：
文献类型：
--
作者：
Schiml-Webb,PatriciaA;Miller,Emily;Deak,Terrence;Hennessy,MichaelB
在新环境中3小时的社会隔离期间，豚鼠幼仔表现出行为反应的初始主动阶段，其特征主要是发声，然后是被动反应阶段，其中幼仔表现出独特的蹲伏，闭眼和广泛的竖毛。先前用α-黑素细胞刺激激素（α-MSH）治疗幼仔减少了每一种被动行为。外周注射促肾上腺皮质激素释放因子（CRF）可加速分离期间被动反应的发生。为了检查CRF是否通过类似于长期分离的机制产生其作用，我们检查了对注射CRF的幼仔给予α-MSH的作用。正如预期的那样，CRF在60分钟的分离期间显著增强了被动反应。通过脑室内输注或腹膜内注射递送的α-MSH显著降低每种被动行为反应，而不显著影响主动行为。这些发现，以及先前的结果表明，α-MSH的抗炎特性是其在长时间分离期间的行为效应的原因，表明外周CRF通过涉及增强促炎活性的机制加速被动反应的诱导。© 2009威利期刊公司. Dev Psychobiol 51：399-407，2009.
During a 3‐hr period of social isolation in a novel environment, guinea pig pups exhibit an initial active phase of behavioral responsiveness, characterized primarily by vocalizing, which is then followed by a stage of passive responsiveness in which pups display a distinctive crouch, eye‐closing, and extensive piloerection. Prior treatment of pups with alpha‐melanocyte‐stimulating hormone (α‐MSH) reduces each of the passive behaviors. The onset of passive responding during separation can be accelerated with peripheral injection of corticotropin‐releasing factor (CRF). To examine whether CRF produces its effects through a mechanism similar to that of prolonged separation, we examined the effect of administering α‐MSH to pups injected with CRF. As expected, CRF markedly enhanced passive responding during a 60‐min period of separation. α‐MSH delivered by either intracerebroventricular infusion or intraperitoneal injection significantly reduced each of the passive behavioral responses without significantly affecting active behavior. These findings, together with previous results indicating that it is the anti‐inflammatory property of α‐MSH that is responsible for its behavioral effects during prolonged separation, suggest that peripheral CRF speeds the induction of passive responding through a mechanism involving enhanced proinflammatory activity. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 399–407, 2009.
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人子宫内膜中存在免疫反应性促肾上腺皮质激素释放激素。
DOI：
10.1210/jcem.81.3.8772574
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
George Mastorakos;C. Scopa;L. Kao;A. Vryonidou;Theodore C. Friedman;D. Kattis;C. Phenekos;Douglas S. Rabin;G. P. Chrousos
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影响因子：
3.3
作者：
H. Chowdrey;S. Lightman;M. Harbuz;Philip J. Larsen;D. S. Jessop
通讯作者：
D. S. Jessop
影响因子：
4.1
作者：
SWANSON, LW;SAWCHENKO, PE;VALE, WW
通讯作者：
VALE, WW
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影响因子：
3
作者：
N. Kalin;S. Shelton;G. Kraemer;W. McKINNEY
通讯作者：
W. McKINNEY
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影响因子：
3
作者：
N. Kalin;S. Shelton;G. Kraemer;W. McKINNEY
通讯作者：
W. McKINNEY