Presence of immunoreactive corticotropin-releasing hormone in human endometrium.
Presence of immunoreactive corticotropin-releasing hormone in human endometrium.
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人子宫内膜中存在免疫反应性促肾上腺皮质激素释放激素。
DOI：
10.1210/jcem.81.3.8772574
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
G. P. Chrousos
中科院分区：
文献类型：
--
作者：
George Mastorakos;C. Scopa;L. Kao;A. Vryonidou;Theodore C. Friedman;D. Kattis;C. Phenekos;Douglas S. Rabin;G. P. Chrousos
免疫反应性CRH （IrCRH）是在实验诱导和自发炎症中局部产生的。产生自分泌或旁分泌的促炎作用。此外，CRH由人胎盘、大鼠间质细胞以及大鼠和人卵巢分泌，参与排卵和黄体溶解的炎症过程，和/或调节甾体生成。最后，体外培养的人上皮细胞和蜕质子宫内膜细胞分泌CRH。为了研究体内人子宫内膜中CRH的存在，我们使用一种多克隆、高度特异性的抗大鼠/人CRH抗体，通过免疫组织化学和提取/RIA对该组织进行了检测。对33名年龄23-43岁（中位年龄33.5岁）的女性进行子宫内膜活检，在月经周期的不同阶段采用线性子宫内膜刮除术进行诊断。在所有检查的样本中，子宫内膜腺细胞的细胞质中都有强烈的IrCRH染色。IrCRH也存在于表现蜕膜反应的子宫内膜基质细胞和局部免疫辅助细胞中。在反相高压液相色谱中，子宫内膜IrCRH分子的迁移率与r/hCRH相似。子宫内膜中存在CRH，特别是在月经周期增殖和分泌阶段的腺上皮中存在CRH，以及其已知的促炎特性，表明这种神经肽可能参与子宫内膜生理学的炎症样现象，如月经脱落、表面上皮修复和/或囊胚着床。脱个体间质细胞中CRH的存在与先前报道的体外脱个体培养子宫内膜间质细胞和胎盘蜕膜产生的CRH一致。
Immunoreactive CRH (IrCRH) is produced locally in experimentally induced and spontaneous inflammation. Where it exerts autocrine or paracrine proinflammatory effects. In addition, CRH is secreted by the human placenta, rat Leydig cells, and rat and human ovaries, where it may participate in the inflammatory processes of ovulation and luteolysis, and/or the regulation of steroidogenesis. Finally, CRH is secreted in vitro by cultured human epithelial and decidualized stromal endometrial cells. To investigate the presence of CRH in human endometrium in vivo, we examined this tissue immunohistochemically and by extraction/RIA using a polyclonal, highly specific antirat/human CRH antibody. Endometrial biopsies from 33 women, aged 23-43 yr (median age, 33.5 yr), were performed by linear endometrial curettage for diagnostic purposes at different stages of the cycle. Intense IrCRH staining was localized in the cytoplasm of cells of the endometrial glands in all samples examined. IrCRH was also found in endometrial stromal cells exhibiting decidual reaction and in local immune accessory cells. The mobility of the endometrial IrCRH molecule was similar to that of r/hCRH in reverse phase high pressure liquid chromatography. The presence of CRH in the endometrium, and more specifically in the glandular epithelium during the proliferative and secretory phases of the menstrual cycle together with its known proinflammatory properties, suggest that this neuropeptide might participate in the inflammatory-like phenomena of endometrial physiology, such as menstrual shedding, surface epithelium repair, and/or implantation of the blastocyst. The presence of CRH in decidualized stromal cells is in accordance with its previously reported production by in vitro decidualized cultured endometrial stromal cells as well as by the placental decidua.
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影响因子：
4.1
作者：
SWANSON, LW;SAWCHENKO, PE;VALE, WW
通讯作者：
VALE, WW
影响因子：
20.3
作者：
S. Tabibzadeh
通讯作者：
S. Tabibzadeh
促肾上腺皮质激素释放因子的化学和生物学特征。
DOI：
10.1016/b978-0-12-571139-5.50010-0
发表时间：
1983
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Vale,W;Rivier,C;Brown,MR;Spiess,J;Koob,G;Swanson,L;Bilezikjian,L;Bloom,F;Rivier,J
通讯作者：
Rivier,J
白介素 1 (IL-1) 对人类子宫内膜功能的调节：IL-1 受体的存在与 IL-1 刺激的前列腺素 E2 产生相关。
DOI：
10.1210/jcem-70-4-1000
发表时间：
1990
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Tabibzadeh,S;Kaffka,KL;Satyaswaroop,PG;Kilian,PL
通讯作者：
Kilian,PL
辣椒素消耗大鼠脊髓和延髓中促肾上腺皮质激素释放因子样免疫反应性神经元。
影响因子：
4.1
作者：
Skofitsch,G;Hamill,GS;Jacobowitz,DM
通讯作者：
Jacobowitz,DM