A cellular switchboard in memory circuits

A cellular switchboard in memory circuits
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存储电路中的蜂窝交换机

DOI:
10.1126/science.add2681
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发表时间:
2022
期刊:
影响因子:
56.9
通讯作者:
Craig M
Craig M
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Craig M

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海马体是大脑中与记忆有关的区域。然而,海马体并不是单独起作用,而是在一个更广泛的大脑区域网络(扩展记忆网络)中运作,其中包括前额叶和内嗅皮层以及丘脑中线核,如重组核(NRe)。这些大脑区域之间的交流对于记忆的获取和巩固,以及空间导航和决策的许多方面都很重要。信息可以通过多种途径在扩展记忆网络中流动,直接和间接的途径都汇聚在海马体上。信息流通过这些不同途径被优先排序的机制在很大程度上仍然是未知的。在这期杂志的第324页,Sakalaret等人报道了一种通过海马体传递信息的细胞机制。
The hippocampus is a brain region that is associated with memory. However, the hippocampus does not function alone, but rather operates within a wider network of brain regions (the extended memory network) including, among other areas, the prefrontal and entorhinal cortices and midline thalamic nuclei, such as nucleus reuniens (NRe) . Communication between these brain regions is important for many aspects of memory acquisition and consolidation, as well as for spatial navigation and decision-making. There are multiple routes through which information can flow through the extended memory network, with direct and indirect pathways converging on the hippocampus. The mechanisms by which information flow through these different pathways is prioritized have remained largely unknown. On page 324 of this issue, Sakalaret al.report a cellular mechanism of information routing through the hippocampus.
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