Adipocytes: active facilitators in epithelial ovarian cancer progression?
Adipocytes: active facilitators in epithelial ovarian cancer progression?
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DOI：
10.1186/s13048-020-00718-4
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发表时间：
2020-09-23
影响因子：
4
通讯作者：
Di W
中科院分区：
文献类型：
--
作者：
Dai L;Song K;Di W
越来越多的证据表明，脂肪细胞在多种癌症的进展中发挥重要作用。此外，在肥胖症中，脂肪细胞改变了其原有功能，并有助于脂肪组织微环境的代谢和炎症变化，这可以进一步促进肿瘤的发展。目前，脂肪细胞在上皮性卵巢癌（EOC）发病机制中的作用尚未完全阐明。本文就脂肪细胞在卵巢上皮性癌发生发展中的作用作一综述。脂肪细胞是上皮性卵巢癌组织的近邻，通过分泌脂肪因子、代谢重塑和免疫微环境调节等途径促进上皮性卵巢癌的生长、侵袭、转移和血管生成。此外，脂肪细胞是重要的治疗靶点，并且可以作为用于EOC治疗的有用的抗癌药物递送库。此外，脂肪细胞也作为治疗障碍，因为它们参与EOC治疗抗性。因此，更好地表征EOC微环境中的脂肪细胞以及脂肪细胞和EOC细胞之间的串扰可以提供对EOC进展的见解，并提出新的治疗机会。
There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, which can further enhance tumor development. At present, the roles of adipocytes in the pathogenesis of epithelial ovarian cancer (EOC) are far from being fully elucidated. Herein, we summarized the recent advances in understanding the roles of adipocytes in EOC progression. Adipocytes, close neighbors of EOC tissue, promote EOC growth, invasion, metastasis and angiogenesis through adipokine secretion, metabolic remodeling and immune microenvironment modulation. Moreover, adipocytes are important therapeutic targets and may work as useful anticancer drug delivery depot for EOC treatment. Furthermore, adipocytes also act as a therapeutic obstacle for their involvement in EOC treatment resistance. Hence, better characterization of the adipocytes in EOC microenvironment and the crosstalk between adipocytes and EOC cells may provide insights into EOC progression and suggest novel therapeutic opportunities.
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影响因子：
4.7
作者：
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通讯作者：
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作者：
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通讯作者：
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DOI：
10.1152/ajpendo.00174.2006
发表时间：
2006-10-01
影响因子：
5.1
作者：
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通讯作者：
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