Haemodynamic changes in hepatocellular carcinoma and liver parenchyma under balloon occlusion of the hepatic artery
Haemodynamic changes in hepatocellular carcinoma and liver parenchyma under balloon occlusion of the hepatic artery
复制标题
肝动脉球囊闭塞下肝细胞癌及肝实质血流动力学变化
DOI：
10.1007/s00330-016-4573-2
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发表时间：
2016
影响因子：
5.9
通讯作者：
Kumita S
中科院分区：
文献类型：
--
作者：
Sugihara F;Murata S;Ueda T;Yasui D;Yamaguchi H;Miki I;Kawamoto C;Uchida E;Kumita S
目的探讨肝动脉阻断对原发性肝癌（HCC）及肝脏血流动力学的影响。在肝动脉造影（CTHA）期间进行了计算机断层扫描（CT），有和没有肝动脉球囊闭塞。在CTHA上测量了球囊阻断前后HCC和肝脏的CT衰减和增强体积。根据HCC与肝脏的衰减比（H/L比）和HCC与肝脏的增强体积的差异来评价球囊位置（节段或亚节段分支）的影响。然而，在亚段组（n = 18）中，球囊闭塞时H/L比显着较高，肝脏增强体积显着较低;有和无球囊闭塞时肝癌增强体积相似。肝段组的H/L比值和增强体积的变化率均低于亚段组。结论肝动脉阻断可引起肝癌和肝脏的血流动力学改变，尤其是节段性阻断。要点·肝动脉阻断可引起肝癌和肝脏的血流动力学改变。·节段性闭塞降低了肝细胞癌与肝脏衰减比的变化率。·亚段闭塞增加了肝细胞癌与肝脏衰减比的变化率。肝动脉阻断使肝癌和肝脏的增强体积减小。肝动脉闭塞导致肝细胞癌灌注缺损。
ObjectivesTo investigate haemodynamic changes in hepatocellular carcinoma (HCC) and liver under hepatic artery occlusion.MethodsThirty-eight HCC nodules in 25 patients were included. Computed tomography (CT) during hepatic arteriography (CTHA) with and without balloon occlusion of the hepatic artery was performed. CT attenuation and enhancement volume of HCC and liver with and without balloon occlusion were measured on CTHA. Influence of balloon position (segmental or subsegmental branch) was evaluated based on differences in HCC-to-liver attenuation ratio (H/L ratio) and enhancement volume of HCC and liver.ResultsIn the segmental group (n = 20), H/L ratio and enhancement volume of HCC and liver were significantly lower with balloon occlusion than without balloon occlusion. However, in the subsegmental group (n = 18), H/L ratio was significantly higher and liver enhancement volume was significantly lower with balloon occlusion; HCC enhancement volume was similar with and without balloon occlusion. Rate of change in H/L ratio and enhancement volume of HCC and liver were lower in the segmental group than in the subsegmental group. There were significantly more perfusion defects in HCC in the segmental group.ConclusionsHepatic artery occlusion causes haemodynamic changes in HCC and liver, especially with segmental occlusion.Key Points•Hepatic artery occlusion causes haemodynamic changes in hepatocellular carcinoma and liver.•Segmental occlusion decreased rate of change in hepatocellular carcinoma-to-liver attenuation ratio.•Subsegmental occlusion increased rate of change in hepatocellular carcinoma-to-liver attenuation ratio.•Hepatic artery occlusion decreased enhancement volume of hepatocellular carcinoma and liver.•Hepatic artery occlusion causes perfusion defects in hepatocellular carcinoma.
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影响因子：
19.7
作者：
Takeuchi, Y;Arai, Y;Itai, Y
通讯作者：
Itai, Y
肝动脉和门静脉血流之间的相互作用；
影响因子：
--
作者：
F. Jakab;Z. Ráth;F. Schmal;P. Nagy;J. Faller
通讯作者：
J. Faller
球囊闭塞动脉灌注——一种抗癌药物给药新方法（作者译）。
DOI：
--
发表时间：
1981
期刊：
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
影响因子：
--
作者：
R. Yamada;S. Yamaguchi;H. Nakatsuka;K. Nakamura;M. Sato;N. Kobayashi;S. Takashima;H. Sangen
通讯作者：
H. Sangen
影响因子：
29.4
作者：
LAUTT, WW;LEGARE, DJ;EZZAT, WR
通讯作者：
EZZAT, WR
影响因子：
3.7
作者：
Ishikawa T;Abe S;Inoue R;Sugano T;Watanabe Y;Iwanaga A;Seki K;Honma T;Nemoto T;Takeda K;Yoshida T
通讯作者：
Yoshida T