Predictive factor of local recurrence after balloon-occluded TACE with miriplatin (MPT) in hepatocellular carcinoma.
Predictive factor of local recurrence after balloon-occluded TACE with miriplatin (MPT) in hepatocellular carcinoma.
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DOI：
10.1371/journal.pone.0103009
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yoshida T
中科院分区：
文献类型：
--
作者：
Ishikawa T;Abe S;Inoue R;Sugano T;Watanabe Y;Iwanaga A;Seki K;Honma T;Nemoto T;Takeda K;Yoshida T
米铂（MPT）是一种新型的铂配合物，用于肝动脉化疗栓塞（TACE），显示出治疗肝细胞癌（HCC）的前景。然而，在某些病例中报告了快速洗脱。因此，已经尝试了施用MPT的各种方法以增加其治疗功效。球囊闭塞TACE（B-TACE）是一种有希望的方法，但B-TACE联合MPT的治疗效果尚未得到评价。探讨原发性肝癌经肝动脉化疗栓塞（B-TACE）联合经皮肝动脉化疗栓塞（MPT）后局部复发的治疗效果及相关因素。本研究纳入了51例直径等于或小于5 cm的HCC病变患者（55个结节），这些患者在2012年1月至2013年6月期间接受了B-TACE和MPT。评价了B-TACE联合MPT后的局部复发以及与局部复发相关的因素。6个月时的总体局部复发率为11.1%，12个月时为26.2%。局部复发率确实存在显著差异，这取决于B-TACE联合MPT后即刻的CT值。多因素分析显示，B-TACE联合MPT术后CT值是唯一与B-TACE术后局部复发相关的因素。B-TACE联合MPT可实现相对较好的肝癌局部控制。术后即刻CT平扫值可作为预测局部复发的指标。对于CT值不满意的患者，需要局部治疗或额外治疗。
Miriplatin (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). However, rapid washout has been reported in some cases. Therefore, various methods of administration with MPT have been attempted to increase its therapeutic efficacy. One hopeful method is balloon-occluded TACE (B-TACE), but the therapeutic efficacy of B-TACE with MPT has not been evaluated. To investigate the treatment outcomes and factors involved in local recurrence after B-TACE with MPT in HCC. This study included 51 patients (55 nodules) with HCC lesions equal or less than 5 cm in diameter who underwent B-TACE with MPT between January 2012 and June 2013. Local recurrence after B-TACE with MPT and factors associated with local recurrence were evaluated. The overall local recurrence rate was 11.1% at 6 months and 26.2% at 12 months. The local recurrence rate did differ significantly depending on CT values immediately after B-TACE with MPT. Multivariate analysis also showed that the CT value after B-TACE with MPT was the only factor related to local recurrence after B-TACE. B-TACE with MPT achieves relatively good local control of HCC. The plain CT value immediately after B-TACE with MPT is a predictive factor for local recurrence. In patients with unsatisfactory CT values, locoregional therapy or additional treatment is required.
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