Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity.
Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity.
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DOI：
10.1016/j.immuni.2018.05.013
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发表时间：
2018-06-19
期刊：
影响因子：
32.4
通讯作者：
Colonna M
中科院分区：
文献类型：
--
作者：
Colonna M
1型、2型和3型先天性淋巴样细胞（ILC）已经作为T辅助细胞-1（Th 1）、Th 2和Th 17细胞的组织驻留先天性相关物而出现。最近的研究表明，ILC比最初提出的更加多样化，这可能反映了ILC真正不同的谱系或适应不同的组织微环境，称为可塑性。鉴于ILC与T细胞惊人地相似，它们是多余的吗？虽然ILC和初级T细胞应答的调节、时间和幅度不同，但组织驻留记忆T细胞可能使ILC在次级应答期间冗余。ILC在免疫中的独特影响可能体现在大量的表面和细胞内受体中，这些受体赋予这些细胞区分正常和致病组分的能力，与其他细胞相互作用，并相应地校准其细胞因子分泌。在这里，我回顾了最近的进展，阐明了ILC的多样性，并讨论其独特的和冗余的功能。先天性淋巴样细胞（inate lymphoid cells，ILC）是Th 1、Th 2和Th 17细胞的组织驻留相关物。科隆纳等al.review在了解ILC多样性和功能可塑性方面的最新进展-它们独特的和冗余的功能，受体库以及基因表达程序的调控。
Type 1, 2 and 3 innate lymphoid cells (ILCs) have emerged as tissue resident innate correlates of T helper-1 (Th1), Th2 and Th17 cells. Recent studies suggest that ILCs are more diverse than originally proposed; this may reflect truly distinct lineages or adaptation of ILCs to disparate tissue microenvironments, known as plasticity. Given that ILCs strikingly resemble T cells, are they redundant? While the regulation, timing and magnitude of ILC and primary T cell responses differ, tissue resident memory T cells may render ILCs redundant during secondary responses. The unique impact of ILCs in immunity is probably embodied in the extensive array of surface and intracellular receptors that endow these cells with the ability to distinguish between normal and pathogenic components, interact with other cells, and calibrate their cytokine secretion accordingly. Here I review recent advances in elucidating the diversity of ILCs and discuss their unique and redundant functions. Innate lymphoid cells (ILCs) are tissue-resident correlates of T helper1-(Th1), Th2 and Th17 cells. Colonna et al.review recent advances in understanding ILC diversity and functional plasticity - their unique and redundant functions, receptor repertoires as well as regulation of gene expression programs.
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影响因子：
30.5
作者：
Cortez VS;Ulland TK;Cervantes-Barragan L;Bando JK;Robinette ML;Wang Q;White AJ;Gilfillan S;Cella M;Colonna M
通讯作者：
Colonna M
影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
产生 IL-17 ST2( ) 2 组先天淋巴细胞在肺部炎症中发挥致病作用
DOI：
10.1016/j.jaci.2018.03.007
发表时间：
2019-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Cai T;Qiu J;Ji Y;Li W;Ding Z;Suo C;Chang J;Wang J;He R;Qian Y;Guo X;Zhou L;Sheng H;Shen L;Qiu J
通讯作者：
Qiu J
影响因子：
32.4
作者：
Basu R;O'Quinn DB;Silberger DJ;Schoeb TR;Fouser L;Ouyang W;Hatton RD;Weaver CT
通讯作者：
Weaver CT
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo