The novel roles of circular RNAs in metabolic organs.
The novel roles of circular RNAs in metabolic organs.
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环状RNA在代谢器官中的新作用
DOI：
10.1016/j.gendis.2017.12.002
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发表时间：
2018-03
期刊：
影响因子：
6.8
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Zhang ZC;Guo XL;Li X
环状RNA(CircRNAs)具有不同于线性RNAs的共价闭合环结构，近年来重新成为一种新的调节因子，并在多种生物过程中发挥作用。通过深度RNA测序(RNA-seq)技术结合生物信息学分析，已经鉴定了一些CircRNA。此外，CircRNA表现出组织和发育特异的表达，表明它们具有潜在的生物学意义。实际上，CircRNAs作为miRNA海绵的功能已经在一些疾病中得到了很好的证明，此外，CircRNAs还可以作为RNA结合蛋白海绵，调节选择性剪接和基因转录。值得注意的是，新出现的证据表明，CircRNAs在动脉粥样硬化性血管疾病、神经系统疾病和肝病等疾病的发展中起着关键作用，并可作为某些疾病的诊断或预测生物标记物。本文主要讨论了CircRNAs作为调节因子参与多种疾病的研究进展，并着重介绍了目前已阐明的一些生物学和致病机制。
Circular RNAs (circRNAs) with a covalently closed loop structure which was different with linear RNAs, recently re-merged as novel regulator and exerted function in multiple biological processes. Through deep RNA sequencing (RNA-seq) technology coupled with bioinformatic analyses, a number of circRNAs has been identified. Moreover, circRNAs exhibit tissue- and development-specific expression indicating their potential biological significance. Actually, function of circRNAs as miRNA sponge has been well demonstrated in some diseases, besides, circRNAs also could function as RNA binding protein sponge and regulate alternative splicing and gene transcription. Notably, Emerging evidences showed that circRNAs played a pivotal role on the development of diseases including atherosclerotic vascular disease, neurological disorders and liver diseases, and served as diagnostic or predictive biomarkers of some diseases. This review mainly discusses the current advance of circRNAs as regulator involved in many diseases, and highlights circRNAs which have been well elucidated biological and pathogenic mechanism.
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影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
circRNA生物合成的调控
影响因子：
4.1
作者：
Chen, Ling-Ling;Yang, Li
通讯作者：
Yang, Li
影响因子：
--
作者：
Fu L;Chen Q;Yao T;Li T;Ying S;Hu Y;Guo J
通讯作者：
Guo J
影响因子：
46.9
作者：
Jeck, William R.;Sharpless, Norman E.
通讯作者：
Sharpless, Norman E.
影响因子：
4.8
作者：
COCQUERELLE, C;MASCREZ, B;BAILLEUL, B
通讯作者：
BAILLEUL, B