Individual non-esterified fatty acids and incident atrial fibrillation late in life.
Individual non-esterified fatty acids and incident atrial fibrillation late in life.
复制标题
生命后期的单个非层化脂肪酸和入射房颤。
DOI：
10.1136/heartjnl-2020-317929
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Kizer JR
中科院分区：
文献类型：
--
作者：
Pellegrini CN;Buzkova P;Lichtenstein AH;Matthan NR;Ix JH;Siscovick DS;Heckbert SR;Tracy RP;Mukamal KJ;Djoussé L;Kizer JR
肥胖和代谢异常是心房颤动（AF）的主要危险因素。脂肪库的扩大与循环中总非酯化脂肪酸（NEFA）的增加有关，NEFA水平升高与AF事件有关。我们对个体NEFA进行了全面的血清测量，以确定与晚期新发AF的特定关联。本研究的重点是从心血管健康研究（一项基于社区的美国老年人纵向研究）中选择的血清可用且无AF的参与者。通过气相色谱法测量了35个单独的NEFA。考克斯回归用于评估个体NEFA与AF事件的相关性。研究样本包括1，872名参与者（年龄77.7±4.4）。在11.3年的中位随访期间，发生了715例AF事件。在同时调整所有NEFA并完全调整潜在混杂因素后，血清神经酸（24：1 n-9）（一种长链单不饱和脂肪酸）浓度较高与AF风险较高相关（HR/SD：1.18; 95% CI：1.08-1.29; p<0.001）。相反，血清中γ-亚麻酸（18：3 n-6）（一种多不饱和n-6脂肪酸）浓度较高与AF风险较低相关（SD HR：0.81; 95%CI：0.71-0.94; p=0.004）。在老年人中，血清非酯化神经酸水平呈正相关，而血清非酯化γ-亚麻酸水平呈负相关，与事件AF。如果得到证实，这些结果可以提供新的策略，AF预防和早期干预在这部分人群中的最高风险。
Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Expansion of fat depots is associated with increased circulating total non-esterified fatty acids (NEFAs), elevated levels of which are associated with incident AF. We undertook comprehensive serum measurement of individual NEFA to identify specific associations with new-onset AF late in life. The present study focused on participants with available serum and free of AF selected from the Cardiovascular Health Study, a community-based longitudinal investigation of older US adults. Thirty-five individual NEFAs were measured by gas chromatography. Cox regression was used to evaluate the association of individual NEFAs with incident AF. The study sample included 1,872 participants (age 77.7±4.4). During median follow-up of 11.3 years, 715 cases of incident AF occurred. After concurrent adjustment of all NEFAs and full adjustment for potential confounders, higher serum concentration of nervonic acid (24:1n-9), a long-chain monounsaturated fatty acid, was associated with higher risk of AF (HR per SD: 1.18; 95% CI: 1.08–1.29; p<0.001). Conversely, higher serum concentration of gamma-linolenic acid (18:3n-6), a polyunsaturated n-6 fatty acid, was associated with lower risk of AF (HR per SD: 0.81; 95% CI: 0.71–0.94; p=0.004). None of the remaining NEFAs was significantly associated with AF. Among older adults, serum levels of non-esterified nervonic acid were positively associated, while serum levels of non-esterified gamma-linolenic acid were inversely associated, with incident AF. If confirmed, these results could offer new strategies for AF prevention and early intervention in this segment of the population at highest risk.
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影响因子：
3.7
作者：
Mortensen LM;Lundbye-Christensen S;Schmidt EB;Calder PC;Schierup MH;Tjønneland A;Parner ET;Overvad K
通讯作者：
Overvad K
影响因子：
5
作者：
Sergeant S;Rahbar E;Chilton FH
通讯作者：
Chilton FH
影响因子：
37.8
作者：
Wu JH;Lemaitre RN;King IB;Song X;Sacks FM;Rimm EB;Heckbert SR;Siscovick DS;Mozaffarian D
通讯作者：
Mozaffarian D
影响因子：
4.8
作者：
Brouwer, IA;Heeringa, J;Witteman, JCM
通讯作者：
Witteman, JCM
影响因子：
4.2
作者：
Chiuve, Stephanie E.;Sandhu, Roopinder K.;Albert, Christine M.
通讯作者：
Albert, Christine M.