A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy.
A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy.
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DOI：
10.1021/ja106855m
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发表时间：
2010-11-03
影响因子：
15
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zhou M;Zhang R;Huang M;Lu W;Song S;Melancon MP;Tian M;Liang D;Li C
我们合成并评估了一类新型的无螯合剂的[64 Cu]-CuS纳米颗粒（NPs），其既适用于PET成像，又适用于光热消融的光热耦合剂。[64 Cu]-CuS纳米颗粒制备简单，具有优异的稳定性，并允许稳健的非侵入性微PET成像。此外，CuS NP在近红外（NIR）区域（峰值930 nm）显示出强吸收，被动靶向偏好肿瘤部位，并且在肿瘤内或静脉内注射后在体外和体内暴露于NIR光时介导U87肿瘤细胞的消融。小直径（~11 nm直径）、强NIR吸收和64 Cu作为结构组分的整合的组合使得[64 Cu]-CuS NPs理想地适用于多功能分子成像和治疗。
We synthesized and evaluated a novel class of chelator-free [64Cu]-CuS nanoparticles (NPs) suitable for both PET imaging and as photothermal coupling agents for photothermal ablation. [64Cu]-CuS NPs were simple to make, possessed excellent stability, and allowed robust noninvasive micro-PET imaging. Furthermore, CuS NPs displayed strong absorption in the near-infrared (NIR) region (peak 930 nm), passive targeting prefers the tumor site, and mediated ablation of U87 tumor cells upon exposure to NIR light both in vitro and in vivo after either intratumoral or intravenous injection. The combination of small diameter (~11 nm diameter), strong NIR absorption, and integration of 64Cu as a structural component makes [64Cu]-CuS NPs ideally suited for multifunctional molecular imaging and therapy.
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影响因子：
11.2
作者：
Lu W;Zhang G;Zhang R;Flores LG 2nd;Huang Q;Gelovani JG;Li C
通讯作者：
Li C
影响因子：
10.8
作者：
Burns AA;Vider J;Ow H;Herz E;Penate-Medina O;Baumgart M;Larson SM;Wiesner U;Bradbury M
通讯作者：
Bradbury M
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
3.7
作者：
McDevitt MR;Chattopadhyay D;Jaggi JS;Finn RD;Zanzonico PB;Villa C;Rey D;Mendenhall J;Batt CA;Njardarson JT;Scheinberg DA
通讯作者：
Scheinberg DA
影响因子：
10.8
作者：
Chen, Jingyi;Wang, Danling;Li, Xingde
通讯作者：
Li, Xingde