Telomere elongation during early development is independent of environmental temperatures in Atlantic salmon
Telomere elongation during early development is independent of environmental temperatures in Atlantic salmon
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大西洋鲑鱼早期发育过程中的端粒伸长与环境温度无关
DOI：
--
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发表时间：
2018
影响因子：
2.8
通讯作者：
N. Metcalfe
中科院分区：
文献类型：
--
作者：
Darryl McLennan;J. Armstrong;D. C. Stewart;S. Mckelvey;W. Boner;P. Monaghan;N. Metcalfe
摘要越来越多的证据表明，位于染色体末端并在染色体保护中起重要作用的端粒在出生后的生命中长度下降，并且是生理状态和预期寿命的有用指标。然而，目前对变温脊椎动物端粒动力学知之甚少，这可能与恒温动物不同，至少部分是由于变温动物生理对环境温度的敏感性。我们在这里报告的实验中，大西洋鲑鱼（萨尔莫salar）饲养通过胚胎和幼虫阶段的发展，并在不同的温度下，为了研究环境温度的影响，在生命早期的端粒动力学，DNA氧化损伤和细胞增殖。端粒长度显着增加之间的胚胎和幼虫的发展阶段。与我们的预期相反，在幼虫期结束时的端粒长度的变化是无关的细胞增殖率或氧化DNA损伤的相对水平，并没有变化之间的温度处理。这项研究表明，鲑鱼能够在早期发育过程中恢复端粒的长度，这可能有助于缓冲早期生活中经历的潜在有害环境影响。总结：作者表明，在鲑鱼中，端粒在胚胎和幼虫发育阶段之间显着延长，并且这不受环境温度的影响。
ABSTRACT There is increasing evidence from endothermic vertebrates that telomeres, which cap the ends of chromosomes and play an important role in chromosome protection, decline in length during postnatal life and are a useful indicator of physiological state and expected lifespan. However, much less is currently known about telomere dynamics in ectothermic vertebrates, which are likely to differ from that of endotherms, at least in part due to the sensitivity of ectotherm physiology to environmental temperature. We report here on an experiment in which Atlantic salmon (Salmo salar) were reared through the embryonic and larval stages of development, and under differing temperatures, in order to examine the effects of environmental temperature during early life on telomere dynamics, oxidative DNA damage and cellular proliferation. Telomere length significantly increased between the embryonic and larval stages of development. Contrary to our expectations, variation in telomere length at the end of the larval stage was unrelated to either cell proliferation rate or the relative level of oxidative DNA damage, and did not vary between the temperature treatments. This study suggests that salmon are able to restore the length of their telomeres during early development, which may possibly help to buffer potentially harmful environmental effects experienced in early life. Summary: The authors show that, in salmon, telomeres significantly lengthen between the embryonic and larval stages of development, and that this is not influenced by environmental temperature.
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生命早期竞争和母体营养对野生猫鼬端粒长度的影响
DOI：
10.17863/cam.12464
发表时间：
2017
期刊：
--
影响因子：
--
作者：
Cram D
通讯作者：
Cram D
影响因子：
3.3
作者：
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Verhulst, Simon
影响因子：
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Cawthon, RM
影响因子：
11.1
作者：
V. Zakian
通讯作者：
V. Zakian
影响因子：
4.9
作者：
Debes, Paul V.;Visse, Marko;Vasemagi, Anti
通讯作者：
Vasemagi, Anti