(18)F-NaF and (18)F-FDG as molecular probes in the evaluation of atherosclerosis.
(18)F-NaF and (18)F-FDG as molecular probes in the evaluation of atherosclerosis.
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DOI：
10.1007/s00259-018-4078-0
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发表时间：
2018-11
影响因子：
9.1
通讯作者：
Alavi A
中科院分区：
文献类型：
--
作者：
McKenney-Drake ML;Moghbel MC;Paydary K;Alloosh M;Houshmand S;Moe S;Salavati A;Sturek JM;Territo PR;Weaver C;Werner TJ;Høilund-Carlsen PF;Sturek M;Alavi A
动脉粥样硬化性疾病的早期发现对于有效预防和管理危及生命的心血管事件如心肌梗死和脑血管意外至关重要。鉴于正电子发射断层扫描（PET）比解剖成像方式（如计算机断层扫描（CT））更早地在疾病过程中可视化动脉粥样硬化的潜力，PET成像的这种应用一直是激烈的科学研究的焦点。尽管18F-FDG在历史上是该领域研究最广泛的PET放射性示踪剂，但越来越多的证据表明18F-NaF也具有重要的诊断和预后价值。在这篇文章中，我们回顾了现有的文献中的应用18F-FDG和18F-NaF作为PET探头在动脉粥样硬化，并提出了原来的动物和人体研究的结果，研究了如何以及18F-NaF摄取与血管钙化和心血管风险。
The early detection of atherosclerotic disease is vital to the effective prevention and management of life-threatening cardiovascular events such as myocardial infarctions and cerebrovascular accidents. Given the potential for positron emission tomography (PET) to visualize atherosclerosis earlier in the disease process than anatomic imaging modalities such as computed tomography (CT), this application of PET imaging has been the focus of intense scientific inquiry. Although 18F-FDG has historically been the most widely studied PET radiotracer in this domain, there is a growing body of evidence that 18F-NaF holds significant diagnostic and prognostic value as well. In this article, we review the existing literature on the application of 18F-FDG and 18F-NaF as PET probes in atherosclerosis and present the findings of original animal and human studies that have examined how well 18F-NaF uptake correlates with vascular calcification and cardiovascular risk.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
DOI：
10.1007/s00259-007-0685-x
发表时间：
2008-04-01
影响因子：
9.1
作者：
Bucerius, Jan;Schmaljohann, Joern;Manka, Christoph
通讯作者：
Manka, Christoph
影响因子：
168.9
作者：
Fowkes, F. Gerald R.;Rudan, Diana;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
影响因子：
9.3
作者：
Derlin, Thorsten;Wisotzki, Christian;Klutmann, Susanne
通讯作者：
Klutmann, Susanne
影响因子：
7.5
作者：
Figueroa, Amparo L.;Subramanian, Sharath S.;Tawakol, Ahmed
通讯作者：
Tawakol, Ahmed