Numerical discrimination in Drosophila melanogaster.
Numerical discrimination in Drosophila melanogaster.
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DOI：
10.1016/j.celrep.2023.112772
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发表时间：
2023-07-25
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
对数字的敏感性是一种至关重要的认知能力。由于缺乏适合系统遗传和神经操作的实验模型，无法发现数字认知所需的神经回路。在这里，我们表明，果蝇苍蝇自发地喜欢包含大量的对象集。这种偏好是由两个测试的数字量之间的比率决定的，这是跨物种的数字认知的特征。个别苍蝇在连续几天保持他们的数字选择。使用数值视觉条件反射范例，我们发现苍蝇能够将蔗糖与数值量联系起来，并且可以通过训练来逆转它们对大量的自发偏好。最后，我们发现，沉默小叶柱状神经元（LC11）减少了更多的对象的偏好，从而确定了无脊椎动物的数字认知的神经元基板。这一发现为系统分析进化保守的对数量敏感性的行为和神经机制铺平了道路。Bengochea等人将果蝇作为数字辨别的行为和神经发生学分析的模型系统。苍蝇自发地喜欢更多的物体，但可以逆转他们的偏好后奖励条件。沉默一组参与小物体检测的视觉神经元（LC11）减少了自发和学习的数字辨别。
Sensitivity to numbers is a crucial cognitive ability. The lack of experimental models amenable to systematic genetic and neural manipulation has precluded discovering neural circuits required for numerical cognition. Here, we demonstrate that Drosophila flies spontaneously prefer sets containing larger numbers of objects. This preference is determined by the ratio between the two numerical quantities tested, a characteristic signature of numerical cognition across species. Individual flies maintained their numerical choice over consecutive days. Using a numerical visual conditioning paradigm, we found that flies are capable of associating sucrose with numerical quantities and can be trained to reverse their spontaneous preference for large quantities. Finally, we show that silencing lobula columnar neurons (LC11) reduces the preference for more objects, thus identifying a neuronal substrate for numerical cognition in invertebrates. This discovery paves the way for the systematic analysis of the behavioral and neural mechanisms underlying the evolutionary conserved sensitivity to numerosity. Bengochea et al. present Drosophila as a model system for the behavioral and neurogenetic analysis of numerical discrimination. Flies spontaneously prefer more objects but can reverse their preference upon reward conditioning. Silencing a group of visual neurons involved in small-object detection (LC11) diminishes the spontaneous and learned numerical discrimination.
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