Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation.
Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation.
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DOI：
10.1016/j.expneurol.2018.09.013
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发表时间：
2019-01
影响因子：
5.3
通讯作者：
Ergul A
中科院分区：
文献类型：
--
作者：
Li W;Valenzuela JP;Ward R;Abdelbary M;Dong G;Fagan SC;Ergul A
糖尿病与中风风险增加和结局恶化有关。先前的研究表明，雄性糖尿病动物在缝合或栓塞大脑中动脉闭塞（MCAO）引起缺血性中风后，具有更大的出血转化（HT）、脑血管系统严重丧失以及不良的行为结果。女性在达到更年期之前可以预防中风，但患有糖尿病的年轻女性患中风的风险更高，并且女性占中风死亡率的大部分。目前的研究假设，即使在年轻的雌性动物中，糖尿病也与中风后更大的血管损伤以及感觉运动和认知结果恶化有关。雄性和雌性对照动物以及糖尿病动物接受短暂的 MCAO，并随访 3 或 14 天，以评估神经血管损伤和修复。 90分钟缺血/再灌注损伤的雄性糖尿病动物中风后血管化指数较低，而60分钟缺血/再灌注损伤的雄性糖尿病动物则没有，而雌性组则没有变化。无论损伤时间长短，雄性和雌性组的认知缺陷都会加剧，而缺血时间较长的雄性糖尿病动物的感觉运动功能障碍会恶化。这些结果表明，糖尿病否定了年轻雌性动物中性行为所提供的保护，中风后血管化模式受到损伤程度的影响，并与两性的功能结果相关。急性缺血性中风后的血管保护可能为糖尿病提供新的治疗策略。
Diabetes is associated with increased risk and worsened outcome of stroke. Previous studies showed that male diabetic animals had greater hemorrhagic transformation (HT), profound loss of cerebral vasculature, and poor behavioral outcomes after ischemic stroke induced by suture or embolic middle cerebral artery occlusion (MCAO). Females are protected from stroke until reaching the menopause age, but young females with diabetes have a higher risk of stroke and women account for the majority of stroke mortality. The current study postulated that diabetes is associated with greater vascular injury and exacerbated sensorimotor and cognitive outcome after stroke even in young female animals. Male and female control and diabetic animals were subjected to transient MCAO and followed for 3 or 14 days to assess the neurovascular injury and repair. The vascularization indices after stroke were lower in male diabetic animals with 90-min but not 60-min ischemia/reperfusion injury, while there was no change in female groups. Cognitive deficits were exacerbated in both male and female groups regardless of the injury period, while the sensorimotor dysfunction was worsened in male diabetic animals with longer ischemia time. These results suggest that diabetes negates the protection afforded by sex in young female animals, and post-stroke vascularization pattern is influenced by the degree of injury and correlates with functional outcome in both sexes. Vasculoprotection after acute ischemic stroke may provide a novel therapeutic strategy in diabetes.
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影响因子：
56.9
作者：
FEENEY, DM;GONZALEZ, A;LAW, WA
通讯作者：
LAW, WA
影响因子：
8.3
作者：
Di Carlo, A;Lamassa, M;Inzitari, D
通讯作者：
Inzitari, D
影响因子：
6.9
作者：
Li W;Ward R;Valenzuela JP;Dong G;Fagan SC;Ergul A
通讯作者：
Ergul A
影响因子：
8.3
作者：
Gorelick PB;Furie KL;Iadecola C;Smith EE;Waddy SP;Lloyd-Jones DM;Bae HJ;Bauman MA;Dichgans M;Duncan PW;Girgus M;Howard VJ;Lazar RM;Seshadri S;Testai FD;van Gaal S;Yaffe K;Wasiak H;Zerna C;American Heart Association/American Stroke Association
通讯作者：
American Heart Association/American Stroke Association
DOI：
10.1124/jpet.111.191296
发表时间：
2012-08-01
影响因子：
3.5
作者：
Kelly-Cobbs, Aisha I.;Prakash, Roshini;Ergul, Adviye
通讯作者：
Ergul, Adviye