The Burden of Pediatric Asthma.
The Burden of Pediatric Asthma.
复制标题
DOI：
10.3389/fped.2018.00186
复制
发表时间：
2018
影响因子：
2.6
通讯作者：
La Grutta S
中科院分区：
文献类型：
--
作者：
Ferrante G;La Grutta S
哮喘是儿童中最常见的慢性疾病，给卫生系统带来了持续的负担。近年来，全球儿童和青少年哮喘症状的患病率增加，特别是在中低收入国家（LMIC）。宿主（遗传学、特应性）和环境因素（微生物暴露、被动吸烟和空气污染）似乎促成了这一趋势。在大城市地区观察到的发病率高于农村地区，总体而言，在工业化国家，突出了空气污染在哮喘发病中的作用。哮喘占全球所有原因的“残疾调整生命年”（残疾调整生命年）/100，000总体估计数的1.1%。儿童死亡率很低，近年来在整个欧洲都有所下降。中低收入国家的儿童在发病率和死亡率方面承受的负担尤其高。全球哮喘相关成本很高，通常分为直接，间接和无形成本。直接成本占总成本的50-80%。哮喘是住院治疗的主要原因之一，在5岁以下儿童中尤为常见，在过去20年中患病率有所上升，主要发生在中低收入国家。间接费用通常高于老年患者，包括与学业和工作有关的损失。无形成本无法量化，因为它们与生活质量受损、体力活动和学习成绩受限有关。实施旨在早期发现哮喘从而提供适当治疗的战略已被证明可有效减轻疾病负担。
Asthma is the most common chronic disease in children, imposing a consistent burden on health system. In recent years, prevalence of asthma symptoms became globally increased in children and adolescents, particularly in Low-Middle Income Countries (LMICs). Host (genetics, atopy) and environmental factors (microbial exposure, exposure to passive smoking and air pollution), seemed to contribute to this trend. The increased prevalence observed in metropolitan areas with respect to rural ones and, overall, in industrialized countries, highlighted the role of air pollution in asthma inception. Asthma accounts for 1.1% of the overall global estimate of “Disability-adjusted life years” (DALYs)/100,000 for all causes. Mortality in children is low and it decreased across Europe over recent years. Children from LMICs particularly suffer a disproportionately higher burden in terms of morbidity and mortality. Global asthma-related costs are high and are usually are classified into direct, indirect and intangible costs. Direct costs account for 50–80% of the total costs. Asthma is one of the main causes of hospitalization which are particularly common in children aged < 5 years with a prevalence that has been increased during the last two decades, mostly in LMICs. Indirect costs are usually higher than in older patients, including both school and work-related losses. Intangible costs are unquantifiable, since they are related to impairment of quality of life, limitation of physical activities and study performance. The implementation of strategies aimed at early detect asthma thus providing access to the proper treatment has been shown to effectively reduce the burden of the disease.
登录
查看更多内容
影响因子：
8
作者：
Galassi, C;De Sario, M;Forastiere, F
通讯作者：
Forastiere, F
影响因子：
76.2
作者：
Gehring, Ulrike;Wijga, Alet H.;Brunekreef, Bert
通讯作者：
Brunekreef, Bert
影响因子：
24.3
作者：
Ellwood, Philippa;Asher, M. Innes;Strachan, David P.
通讯作者：
Strachan, David P.
DOI：
10.5588/ijtld.14.0170
发表时间：
2014-11-01
影响因子：
4
作者：
Asher, I.;Pearce, N.
通讯作者：
Pearce, N.
DOI：
10.1164/rccm.200906-0858oc
发表时间：
2010-03-15
影响因子：
24.7
作者：
Gehring, Ulrike;Wijga, Alet H.;Brunekreef, Bert
通讯作者：
Brunekreef, Bert