Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies.
Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies.
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DOI：
10.1002/npr2.12031
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发表时间：
2018-12
影响因子：
2.5
通讯作者：
van Erp TGM
中科院分区：
文献类型：
--
作者：
Nakahara S;Matsumoto M;van Erp TGM
海马区被认为是精神分裂症病理生理学中的关键区域，但海马区异常的性质及其对疾病表达的贡献仍有待完全确定。这项研究回顾了过去十年发表的精神分裂症海马区体积和生理成像研究的结果。在PubMed数据库中搜索有关精神分裂症的海马区体积和生理异常的文献，并对其结果进行综述。主要重复的发现包括精神分裂症中CA1体积和CA1过度激活，这可能预示着临床上精神病高危个体的转换，在首发精神分裂症中CA1和CA4/DG体积较小，以及更广泛的海马区体积较小且病程较长。一些研究已经报道了海马区体积与陈述性记忆或症状严重程度之间的关系。总而言之，这些研究为精神分裂症的海马体形成回路模型提供了支持。必须谨慎对待这些初步发现，因为科学界正在积极改进和验证海马区方法。进一步提高我们对精神分裂症涉及的海马区的性质的理解将需要收集亚毫米体素分辨率的结构和生理成像数据，图谱的标准化和一致性，对可能的混杂因素的充分控制，以及对结果的多方法验证。尽管对最初的发现需要谨慎的解释，但我们认为，精神分裂症海马区异常定位的改进有望识别疾病致病机制。海马区被认为是精神分裂症病理生理学中的关键区域，但海马区异常的性质及其对疾病表达的贡献仍有待完全确定。这项研究回顾了过去十年发表的精神分裂症海马区体积和生理成像研究的结果。
The hippocampus is considered a key region in schizophrenia pathophysiology, but the nature of hippocampal subregion abnormalities and how they contribute to disease expression remain to be fully determined. This study reviews findings from schizophrenia hippocampal subregion volumetric and physiological imaging studies published within the last decade. The PubMed database was searched for publications on hippocampal subregion volume and physiology abnormalities in schizophrenia and their findings were reviewed. The main replicated findings include smaller CA1 volumes and CA1 hyperactivation in schizophrenia, which may be predictive of conversion in individuals at clinical high risk of psychosis, smaller CA1 and CA4/DG volumes in first‐episode schizophrenia, and more widespread smaller hippocampal subregion volumes with longer duration of illness. Several studies have reported relationships between hippocampal subregion volumes and declarative memory or symptom severity. Together these studies provide support for hippocampal formation circuitry models of schizophrenia. These initial findings must be taken with caution as the scientific community is actively working on hippocampal subregion method improvement and validation. Further improvements in our understanding of the nature of hippocampal formation subregion involvement in schizophrenia will require the collection of structural and physiological imaging data at submillimeter voxel resolution, standardization and agreement of atlases, adequate control for possible confounding factors, and multi‐method validation of findings. Despite the need for cautionary interpretation of the initial findings, we believe that improved localization of hippocampal subregion abnormalities in schizophrenia holds promise for the identification of disease contributing mechanisms. The hippocampus is considered a key region in schizophrenia pathophysiology but the nature of hippocampal subregion abnormalities and how they contribute to disease expression remains to be fully determined. This study reviews findings from schizophrenia hippocampal subregion volumetric and physiological imaging studies published within the last decade.
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DOI：
10.1038/npp.2017.5
发表时间：
2017-05
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
Ho NF;Holt DJ;Cheung M;Iglesias JE;Goh A;Wang M;Lim JK;de Souza J;Poh JS;See YM;Adcock AR;Wood SJ;Chee MW;Lee J;Zhou J
通讯作者：
Zhou J
影响因子：
6.6
作者：
Dwork, AJ
通讯作者：
Dwork, AJ
影响因子：
10.6
作者：
Benes, FM
通讯作者：
Benes, FM
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
10.6
作者：
Bearden, Carrie E.;Thompson, Paul M.;Soares, Jair C.
通讯作者：
Soares, Jair C.