Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.
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DOI：
10.1016/j.freeradbiomed.2011.06.011
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发表时间：
2011-10-01
影响因子：
7.4
通讯作者：
Pagano, Patrick J.
中科院分区：
文献类型：
--
作者：
Al Ghouleh, Imad;Khoo, Nicholas K. H.;Knaus, Ulla G.;Griendling, Kathy K.;Touyz, Rhian M.;Thannickal, Victor J.;Barchowsky, Aaron;Nauseef, William M.;Kelley, Eric E.;Bauer, Phillip M.;Darley-Usmar, Victor;Shiva, Sruti;Cifuentes-Pagano, Eugenia;Freeman, Bruce A.;Gladwin, Mark T.;Pagano, Patrick J.
关键词：
活性氧（ROS）参与许多生理和病理生理反应。越来越多的证据表明ROS作为信号分子参与细胞途径的传播。NADPH氧化酶（Nox）家族是细胞内ROS的主要来源，与许多疾病的进展甚至环境毒性有关。该家族对细胞过程的影响的复杂性源于这样的事实，即有7个成员，每个成员具有独特的组织分布，细胞定位和表达。Nox蛋白在激活机制和作为其产物检测到的主要ROS方面也不同。为了增加这种复杂性，越来越多的证据表明，其他细胞氧化酶或其产物可能参与Nox调节。细胞的整体氧化还原和代谢状态，特别是线粒体，也对ROS信号传导有影响。亲电脂肪酸等分子的信号传导对许多氧化还原敏感性病理有影响，因此，作为抗炎分子，有助于ROS调节的复杂性。以下综述基于最近在匹兹堡大学血管医学研究所和药理学与化学生物学系举行的国际氧化酶信号传导研讨会的会议记录，并包括演讲者之间的进一步互动和讨论。
Reactive oxygen species (ROS) are involved in numerous physiological and pathophysiological responses. Increasing evidence implicates ROS as signaling molecules involved in the propagation of cellular pathways. The NADPH oxidase (Nox) family of enzymes is a major source of ROS in the cell and has been related to the progression of many diseases and even in environmental toxicity. The complexity of this family’s effects on cellular processes stems from the fact that there are 7 members, each with unique tissue distribution, cellular localization and expression. Nox proteins also differ in activation mechanisms and the major ROS detected as their product. To add to this complexity, mounting evidence suggests that other cellular oxidases or their products may be involved in Nox regulation. The overall redox and metabolic status of the cell, specifically the mitochondria, also has implications on ROS signaling. Signaling of such molecules as electrophillic fatty acids has impact on many redox sensitive pathologies, and thus, as anti-inflammatory molecules, contributes to the complexity of ROS regulation. The following review is based on the proceedings of a recent international Oxidase Signaling Symposium at the University of Pittsburgh’s Vascular Medicine Institute and Department of Pharmacology and Chemical Biology, and encompasses further interaction and discussion among the presenters.
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