Two alternating motor programs drive navigation in Drosophila larva.
Two alternating motor programs drive navigation in Drosophila larva.
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DOI：
10.1371/journal.pone.0023180
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Samuel AD
中科院分区：
文献类型：
--
作者：
Lahiri S;Shen K;Klein M;Tang A;Kane E;Gershow M;Garrity P;Samuel AD
当放置在温度梯度上时，果蝇幼虫通过调节连续向前运动期间的重新定向动作的大小、频率和方向来远离过冷或过热。向前的运动是由从尾部到头部的波浪驱动的。在每次调整方向的过程中，幼虫会停下来，把头从一边扫到另一边，直到找到一个新的前进方向。在这里，我们的特点是电机程序的启动，执行和完成的重定向演习通过测量身体段动态的自由移动的幼虫与荧光肌纤维，因为他们暴露在温度的时间变化。我们发现，重定向演习的特点是高度定型的时空模式段动态。重新定向动作开始于头部扫动，头部扫动由前体部分的不对称收缩驱动。幼虫在头部扫过运动后通过使用逐渐推动后部身体节段与尾部不对齐的摆动波来获得向前运动的新方向（即，向前运动的先前方向）与头部对准。因此，在趋热性期间的重定向动作由两个交替的运动程序执行：（1）用于驱动向前运动的伸展和（2）用于驱动头部扫动运动的前部身体节段的不对称收缩。
When placed on a temperature gradient, a Drosophila larva navigates away from excessive cold or heat by regulating the size, frequency, and direction of reorientation maneuvers between successive periods of forward movement. Forward movement is driven by peristalsis waves that travel from tail to head. During each reorientation maneuver, the larva pauses and sweeps its head from side to side until it picks a new direction for forward movement. Here, we characterized the motor programs that underlie the initiation, execution, and completion of reorientation maneuvers by measuring body segment dynamics of freely moving larvae with fluorescent muscle fibers as they were exposed to temporal changes in temperature. We find that reorientation maneuvers are characterized by highly stereotyped spatiotemporal patterns of segment dynamics. Reorientation maneuvers are initiated with head sweeping movement driven by asymmetric contraction of a portion of anterior body segments. The larva attains a new direction for forward movement after head sweeping movement by using peristalsis waves that gradually push posterior body segments out of alignment with the tail (i.e., the previous direction of forward movement) into alignment with the head. Thus, reorientation maneuvers during thermotaxis are carried out by two alternating motor programs: (1) peristalsis for driving forward movement and (2) asymmetric contraction of anterior body segments for driving head sweeping movement.
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影响因子：
25
作者：
Louis, Matthieu;Huber, Thomas;Vosshall, Leslie B.
通讯作者：
Vosshall, Leslie B.
影响因子：
2.4
作者：
Rodriguez Moncalvo VG;Campos AR
通讯作者：
Campos AR
影响因子：
2.5
作者：
Clark, Damon A.;Gabel, Christopher V.;Samuel, Aravinthan D. T.
通讯作者：
Samuel, Aravinthan D. T.
DOI：
10.1073/pnas.0710168105
发表时间：
2008-04-08
影响因子：
11.1
作者：
Sitaraman, Divya;Zars, Melissa;Zars, Troy
通讯作者：
Zars, Troy
影响因子：
64.8
作者：
BERG, HC;BROWN, DA
通讯作者：
BROWN, DA