Orbitofrontal sulcogyral morphology is a transdiagnostic indicator of brain dysfunction.
Orbitofrontal sulcogyral morphology is a transdiagnostic indicator of brain dysfunction.
复制标题
DOI：
10.1016/j.nicl.2017.12.021
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Troiani V
中科院分区：
文献类型：
--
作者：
Patti MA;Troiani V
眶额皮质（OFC）的非典型沟回模式与精神分裂症的风险增加有关，以及与精神分裂症相关的数量性状，如快感缺乏。在这里，我们进行了跨诊断比较，以评估是否非典型的眶额皮层沟回模式赋予多种脑部疾病的风险。我们检查了4组成年参与者（N = 189）的结构图像，包括诊断为精神分裂症（SZ; N = 49），双相情感障碍（BP; N = 46），注意缺陷多动障碍（ADHD; N = 41）和对照组（N = 53）。根据眶额沟内侧和外侧的连续性确定眶额沟回类型。进行卡方分析，以比较患者组和对照组之间的沟回模式频率分布。我们发现SZ组和BP组均具有非典型模式分布，相对于对照组，左半球的非典型模式频率增加，这与这些疾病的重叠临床特征和遗传病因学一致（SZ：χ2 = 17.6; p < 0.001; BP：χ2 = 19.2，p < 0.001）。ADHD组的分布与对照组无显著差异（χ2 = 5.5; p = 0.06，NS）。在BP和SZ之间相似的沟回模式频率表明，沟回表型可能更直接地映射到一个性状，是transdiagnosis。这些结果表明，脑沟回模式提出了一种新的形态学指标增加的易感性，以多种精神病诊断。精神分裂症和双相情感障碍患者共同眶额沟回型（I型）患病率降低精神分裂症中II型和III型模式以及双相情感障碍中III型模式的患病率增加。表明非典型眶额沟回模式不仅限于精神分裂症患者。
Atypical sulcogyral patterns in the orbitofrontal cortex (OFC) are associated with increased risk for schizophrenia, as well as with quantitative traits associated with schizophrenia, such as anhedonia. Here we conduct a cross-diagnostic comparison to assess whether atypical OFC sulcogyral patterns confer risk for multiple brain disorders. We examined structural images from 4 groups of adult participants (N = 189), including those diagnosed with schizophrenia (SZ; N = 49), bipolar disorder (BP; N = 46), attention deficit hyperactivity disorder (ADHD; N = 41), and controls (N = 53). OFC sulcogyral pattern types were determined based on the continuity of the medial and lateral orbitofrontal sulcus. Chi-square analysis was performed to compare the sulcogyral pattern frequency distributions between patient groups and controls. We find that both SZ and BP groups had atypical pattern distributions, with increased atypical pattern frequencies relative to controls in the left hemisphere, consistent with the overlapping clinical features and genetic etiology of these disorders (SZ: χ2 = 17.6; p < 0.001; BP: χ2 = 19.2, p < 0.001). The ADHD group distribution did not significantly differ from controls (χ2 = 5.5; p = 0.06, NS.). Similar sulcogyral pattern frequencies across BP and SZ suggest that the sulcogyral phenotype may map more directly to a trait that is transdiagnostic. These results suggest that sulcogyral patterns present a novel morphological indicator for increased susceptibility to multiple psychiatric diagnoses. Decreased prevalence of common orbitofrontal sulcogyral pattern (Type I) in patients with schizophrenia and bipolar disorder. Increased prevalence of Type II and III patterns in schizophrenia and Type III patterns in bipolar disorder. Suggests that atypical orbitofrontal sulcogyral patterns are not limited to patients with schizophrenia.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
4.5
作者：
Lavoie, Suzie;Bartholomeuz, Cali F.;Wood, Stephen J.
通讯作者：
Wood, Stephen J.
精神障碍的负担。
影响因子：
5.5
作者：
Eaton WW;Martins SS;Nestadt G;Bienvenu OJ;Clarke D;Alexandre P
通讯作者：
Alexandre P
影响因子：
1.7
作者：
Adler, L;Cohen, J
通讯作者：
Cohen, J
影响因子：
0.9
作者：
Jackson KJ;Fanous AH;Chen J;Kendler KS;Chen X
通讯作者：
Chen X