Amyloid burden and neural function in people at risk for Alzheimer's Disease.
Amyloid burden and neural function in people at risk for Alzheimer's Disease.
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DOI：
10.1016/j.neurobiolaging.2013.09.028
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发表时间：
2014-03
影响因子：
4.2
通讯作者：
Sager MA
中科院分区：
文献类型：
--
作者：
Johnson SC;Christian BT;Okonkwo OC;Oh JM;Harding S;Xu G;Hillmer AT;Wooten DW;Murali D;Barnhart TE;Hall LT;Racine AM;Klunk WE;Mathis CA;Bendlin BB;Gallagher CL;Carlsson CM;Rowley HA;Hermann BP;Dowling NM;Asthana S;Sager MA
为了确定有阿尔茨海默病（AD）风险的健康成人中淀粉样蛋白负荷与神经功能之间的关系，我们对201名受试者使用了多模式成像，包括[C-11]匹兹堡化合物B正电子发射断层扫描、[F-18]氟脱氧葡萄糖、正电子发射断层扫描和磁共振成像，以及认知测量（平均年龄，60.1岁;范围，46-73岁）来自威斯康星州阿尔茨海默病预防登记处。使用定性评级，18%的样本为β-淀粉样蛋白强阳性（Ab+），41%为不确定（Aβi），41%为阴性（Aβ-）。Aβ+与年龄较大、女性相关，并显示AD和APOE 4的母体家族史趋势。相对于Aβ-组，Aβ+和Aβi参与者双侧丘脑的葡萄糖代谢增加; Aβ+参与者双侧上级颞回的代谢也增加。相对于Aβ-组，Aβ+参与者双侧外侧顶叶灰质增加，无明显萎缩区域。认知表现和自我报告的认知和情感症状没有组间差异。淀粉样蛋白负荷可在平均年龄60岁的成人中确定，并伴有特定区域的糖代谢增加，但不伴有萎缩或认知丧失。这个无症状阶段可能是一个适当的干预窗口，以防止进展为症状性AD。
To determine the relationship between amyloid burden and neural function in healthy adults at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11]Pittsburgh compound B positron emission tomography, [F-18]fluorodeoxyglucose, positron emission tomography, and magnetic resonance imaging, together with cognitive measurement in 201 subjects (mean age, 60.1 years; range, 46–73 years) from the Wisconsin Registry for Alzheimer's Prevention. Using a qualitative rating, 18% of the samples were strongly positive Beta-amyloid (Ab+), 41% indeterminate (Aβi), and 41% negative (Aβ–). Aβ+ was associated with older age, female sex, and showed trends for maternal family history of AD and APOE4. Relative to the Aβ– group, Aβ+ and Aβi participants had increased glucose metabolism in the bilateral thalamus; Aβ+ participants also had increased metabolism in the bilateral superior temporal gyrus. Aβ+ participants exhibited increased gray matter in the lateral parietal lobe bilaterally relative to the Aβ– group, and no areas of significant atrophy. Cognitive performance and self report cognitive and affective symptoms did not differ between groups. Amyloid burden can be identified in adults at a mean age of 60 years and is accompanied by glucometabolic increases in specific areas, but not atrophy or cognitive loss. This asymptomatic stage may be an opportune window for intervention to prevent progression to symptomatic AD.
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影响因子：
11.2
作者：
Landau, Susan M.;Mintun, Mark A.;Joshi, Abhinay D.;Koeppe, Robert A.;Petersen, Ronald C.;Aisen, Paul S.;Weiner, Michael W.;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
9.9
作者：
Honea, R. A.;Swerdlow, R. H.;Burns, J. M.
通讯作者：
Burns, J. M.
影响因子：
14.5
作者：
Chetelat, Gael;Villemagne, Victor L.;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.
基础大脑代谢可能会调节Abeta在轻度认知障碍中的认知作用：大脑储备的一个例子。
DOI：
10.1523/jneurosci.3669-09.2009
发表时间：
2009-11-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cohen AD;Price JC;Weissfeld LA;James J;Rosario BL;Bi W;Nebes RD;Saxton JA;Snitz BE;Aizenstein HA;Wolk DA;Dekosky ST;Mathis CA;Klunk WE
通讯作者：
Klunk WE
DOI：
10.1016/j.jalz.2011.03.004
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jack CR Jr;Albert MS;Knopman DS;McKhann GM;Sperling RA;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH