A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord.
A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord.
复制标题
DOI：
10.1038/s41598-021-94047-1
复制
发表时间：
2021-07-21
影响因子：
4.6
通讯作者：
Horner PJ
中科院分区：
文献类型：
--
作者：
Hogan MK;Barber SM;Rao Z;Kondiles BR;Huang M;Steele WJ;Yu C;Horner PJ
脊髓损伤后，颈脊髓的电刺激作为一种治疗方法正在获得牵引力;然而，与直接放置脊柱内金属丝电极相比，使用非穿透性刺激难以靶向啮齿动物的颈部运动区。已经在啮齿动物和猪模型中探索了穿透线电极，并且虽然它们已经证明在损伤的脊髓中是有益的，但是脊髓实质穿透的负面方面（例如，神经胶质增生、神经组织损伤和顽固性炎症）在考虑治疗潜力时是值得关注的。因此，我们设计了一种新的方法，使用无线刺激系统和腹侧电极阵列的大鼠脊髓硬膜外刺激。我们的方法允许在手术后保留活动性，并且适用于清醒的自由功能动物的长期刺激策略。此外，腹侧脊髓的电生理映射显示腹侧方法适合于大鼠前肢的目标肌肉群，并且在单个电极引线位置处，可以应用不同的刺激方案来实现前肢肌肉的独特激活模式。
Electrical stimulation of the cervical spinal cord is gaining traction as a therapy following spinal cord injury; however, it is difficult to target the cervical motor region in a rodent using a non-penetrating stimulus compared with direct placement of intraspinal wire electrodes. Penetrating wire electrodes have been explored in rodent and pig models and, while they have proven beneficial in the injured spinal cord, the negative aspects of spinal parenchymal penetration (e.g., gliosis, neural tissue damage, and obdurate inflammation) are of concern when considering therapeutic potential. We therefore designed a novel approach for epidural stimulation of the rat spinal cord using a wireless stimulation system and ventral electrode array. Our approach allowed for preservation of mobility following surgery and was suitable for long term stimulation strategies in awake, freely functioning animals. Further, electrophysiology mapping of the ventral spinal cord revealed the ventral approach was suitable to target muscle groups of the rat forelimb and, at a single electrode lead position, different stimulation protocols could be applied to achieve unique activation patterns of the muscles of the forelimb.
登录
查看更多内容
影响因子：
41.2
作者：
通讯作者：
--
DOI：
10.1126/science.1232437
发表时间：
2013-04-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kim TI;McCall JG;Jung YH;Huang X;Siuda ER;Li Y;Song J;Song YM;Pao HA;Kim RH;Lu C;Lee SD;Song IS;Shin G;Al-Hasani R;Kim S;Tan MP;Huang Y;Omenetto FG;Rogers JA;Bruchas MR
通讯作者：
Bruchas MR
影响因子：
4
作者：
Kasten MR;Sunshine MD;Secrist ES;Horner PJ;Moritz CT
通讯作者：
Moritz CT
影响因子：
2.4
作者：
Kombos, T;Suess, O;Brock, M
通讯作者：
Brock, M
DOI：
10.1073/pnas.1505383112
发表时间：
2015-09-29
影响因子：
11.1
作者：
McPherson, Jacob G.;Miller, Robert R.;Perlmutter, Steve I.
通讯作者：
Perlmutter, Steve I.