Trends of HIV incidence and prevalence among men who have sex with men in Beijing, China: Nine consecutive cross-sectional surveys, 2008-2016.
Trends of HIV incidence and prevalence among men who have sex with men in Beijing, China: Nine consecutive cross-sectional surveys, 2008-2016.
复制标题
DOI：
10.1371/journal.pone.0201953
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Chen Q;Sun Y;Sun W;Hao M;Li G;Su X;Xin R;Lu H
在过去的十年中，中国男男性行为者（MSM）中的艾滋病病毒性传播显著增加。艾滋病发病率是艾滋病监测的一个重要指标，我们使用HIV-1 BED捕获酶免疫分析（BED-CEIA）检测了2008 - 2016年北京市男男性行为者的发病率。还评估了与最近感染艾滋病毒有关的风险因素。从2008年到2016年，每年对MSM进行一次对比性横断面调查。收集人口统计学和行为学数据。确定HIV状态，并使用BED-CEIA检测HIV阳性标本的近期感染。ODn值≤0.8的标本视为近期感染，然后计算HIV发病率和患病率。通过单因素和多因素logistic回归分析评估与近期HIV感染相关的危险因素。由2008年至2016年，连续九年合资格参加计划的人数介乎472至616人。所有261例合格的HIV阳性标本均接受了近期HIV感染检测。HIV感染率为5.0%（3.3%~ 6.8%）~ 10.2%（7.8%~ 12.7%），发病率为1.57%（0.19%~ 2.95%）~ 6.63%（3.65%~ 9.61%）。在过去6个月内与男性肛交时从不或有时使用安全套（aOR = 1.515，95%CI：1.016-2.257，p = 0.041）或有梅毒感染史（aOR = 1.561，95%CI：0.946-2.575，p = 0.081）的MSM近期感染HIV的可能性更大。北京居民（aOR = 0.409，95%CI：0.212-0.790，p = 0.008）或过去6个月内仅有一名男性肛交性伴（aOR = 0.467，95%CI：0.220-0.994，p = 0.048）与近期感染HIV的风险较低相关。北京市男男性行为人群HIV感染率呈波动性。无保护的肛交、多性伴、非京籍、梅毒感染是近期HIV感染的重要原因。应继续加强有效的艾滋病和梅毒预防控制干预措施。
Sexual transmission of HIV among men who have sex with men (MSM) increased markedly in China during the past decade. HIV incidence is a critical indicator in HIV surveillance and we use a HIV-1 BED-capture-enzyme immunoassay (BED-CEIA) to examine the incidence among MSM in Beijing from 2008 to 2016. Risk factors related to recent HIV infection were also assessed. Consecutive cross-sectional surveys on MSM were conducted yearly from 2008 through 2016. Demographic and behaviors data were collected. HIV status was determined and HIV positive specimens were tested for recent infection using BED-CEIA. Specimens with ODn values≤0.8 were considered recently infected, HIV incidence rates and prevalence were then calculated. Risk factors associated with recent HIV infection were assessed by univariate and multivariable logistic regression. From 2008 to 2016, the numbers of eligible participants in the nine consecutive years ranged from 472 to 616. All the 261 eligible HIV-positive specimens were subjected to recent HIV infection testing. HIV prevalence ranged from 5.0% (3.3%-6.8%) to 10.2% (7.8%-12.7%), and incidence ranged from 1.57% (0.19%-2.95%) to 6.63% (3.65%-9.61%). MSM who never or sometimes used condoms during anal sex with men in the past 6 months (aOR = 1.515, 95%CI: 1.016–2.257, p = 0.041), or having syphilis infection (aOR = 1.561, 95%CI: 0.946–2.575, p = 0.081) were more likely to be recently infected with HIV. Being a Beijing resident (aOR = 0.409, 95%CI: 0.212–0.790, p = 0.008), or having only one male anal sex partner in the past 6 months (aOR = 0.467, 95%CI: 0.220–0.994, p = 0.048) were associated with a lower risk for recent HIV infection. The HIV incidence fluctuated among MSM in Beijing. Unprotected anal sex, having multiple sex partners, being a non-registered Beijing resident and having a syphilis infection play important roles in the recent HIV infection. Effective intervention measures for HIV and syphilis control and prevention should be continuously strengthened.
登录
查看更多内容
影响因子：
11.8
作者：
Wu, Zunyou;Xu, Jie;Wang, Yu
通讯作者：
Wang, Yu
影响因子：
3.3
作者：
Deane, Kevin D.;Parkhurst, Justin O.;Johnston, Deborah
通讯作者：
Johnston, Deborah
影响因子：
1.9
作者：
Celik, Deniz Gozde;Yuksel, Pelin;Kocazeybek, Bekir
通讯作者：
Kocazeybek, Bekir
影响因子：
8.4
作者：
Xu, Junjie;Wang, Haibo;Wang, Ning
通讯作者：
Wang, Ning
DOI：
10.1155/2013/176459
发表时间：
2013
期刊：
Journal of sexually transmitted diseases
影响因子：
--
作者：
Chun HM;Carpenter RJ;Macalino GE;Crum-Cianflone NF
通讯作者：
Crum-Cianflone NF