Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects.
Association between a polymorphism of aminolevulinate dehydrogenase (ALAD) gene and blood lead levels in Japanese subjects.
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DOI：
10.3390/ijerph6030999
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发表时间：
2009-03
影响因子：
--
通讯作者：
Nakayama T
中科院分区：
文献类型：
--
作者：
Miyaki K;Lwin H;Masaki K;Song Y;Takahashi Y;Muramatsu M;Nakayama T
这项横断面研究调查了 101 名日本工人的氨基乙酰丙酸脱氢酶 (ALAD) 基因型与血铅水平之间的关系。进行了血铅浓度测量、生物标志物和基因分型。 ALAD (ALAD2) 的次要等位基因频率 (MAF) 为 0.08。虽然杂合子GC基因型受试者的血铅水平显着高于纯合子GG基因型受试者，但基因型间血红蛋白、红细胞压积、血清和尿ALA水平无显着差异。 ALAD2 基因型与血铅浓度显着相关，即使在环境铅暴露的受试者中也是如此。还需要大样本进一步确认。
This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
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影响因子：
3.4
作者：
Chia, SE;Yap, E;Chia, KS
通讯作者：
Chia, KS
影响因子：
3.5
作者：
GOYER, RA
通讯作者：
GOYER, RA
影响因子：
10.4
作者：
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通讯作者：
Claudio, L
DOI：
10.1097/00043764-199810000-00011
发表时间：
1998-10-01
影响因子：
3.2
作者：
Sithisarankul, P;Schwartz, BS;Strickland, PT
通讯作者：
Strickland, PT
影响因子：
10.4
作者：
WETMUR, JG
通讯作者：
WETMUR, JG