The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined.
The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined.
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DOI：
10.1016/j.spen.2009.09.005
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发表时间：
2009-12
影响因子：
2.7
通讯作者：
Volpe, Joseph J.
中科院分区：
文献类型：
--
作者：
Volpe, Joseph J.
新生儿神经学领域，特别是其对早产儿的关注，在神经病理学研究中有其开端。从那时起，先进成像技术的发展引导我们对新生儿脑损伤的病因和性质的理解不断发展。这篇综述提出了一个概念，即新生儿脑损伤对随后的大脑发育有严重和多样的影响，这些影响在决定神经系统预后方面可能比简单的组织损失更重要。早产儿脑损伤最能说明这一概念。这种“早产儿脑病”在人类妊娠最后16-20周期间积极进行的一系列显著发育事件的背景下进行审查。最近通过先进的MRI和神经病理学技术对早产幸存者大脑异常的研究表明，这种脑病是一种复杂的破坏性和发育障碍的混合体。强调了脑病发生的破坏性和发育机制之间的相互关系。在未来，新生儿神经病学的进展可能会重申该领域对神经病理学研究的依赖，包括发育神经生物学中的新细胞和分子方法。
The field of neonatal neurology, and specifically its focus on the premature infant, had its inception in neuropathological studies. Since then, the development of advanced imaging techniques has guided our developing understanding of the etiology and nature of neonatal brain injury. This review promotes the concept that neonatal brain injury has serious and diverse effects on subsequent brain development, and that these effects likely are more important than simple tissue loss in determining neurological outcome. Brain injury in the premature infant is best illustrative of this concept. This “encephalopathy of prematurity” is reviewed in the context of the remarkable array of developmental events actively proceeding during the last 16-20 weeks of human gestation. Recent insights into the brain abnormalities in survivors of preterm birth obtained by both advanced MRI and neuropathological techniques suggest that this encephalopathy is a complex amalgam of destructive and developmental disturbances. The interrelations between destructive and developmental mechanisms in the genesis of the encephalopathy are emphasized. In the future, advances in neonatal neurology will likely reiterate the field's dependence upon neuropathological studies, including new cellular and molecular approaches in developmental neurobiology.
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DOI：
10.1001/archpedi.1987.04460060035027
发表时间：
1987-06-01
影响因子：
--
作者：
ARMSTRONG, DL;SAULS, CD;GODDARDFINEGOLD, J
通讯作者：
GODDARDFINEGOLD, J
影响因子：
3.4
作者：
Agresti, C;DUrso, D;Levi, G
通讯作者：
Levi, G
影响因子：
4.2
作者：
Buntinx, M;Moreels, M;Ameloot, M
通讯作者：
Ameloot, M
影响因子：
3.8
作者：
Allin, M;Henderson, M;Murray, R
通讯作者：
Murray, R
影响因子：
4.2
作者：
Bell, MJ;Hallenbeck, JM
通讯作者：
Hallenbeck, JM