Basophils, IgE, and autoantibody-mediated kidney disease.
Basophils, IgE, and autoantibody-mediated kidney disease.
复制标题
DOI：
10.4049/jimmunol.1002648
复制
发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Min B
中科院分区：
文献类型：
--
作者：
Bosch X;Lozano F;Cervera R;Ramos-Casals M;Min B
Basophils are of interest in immunology due to their ability to produce a Th2-signature cytokine, IL-4, following activation. New understanding of the role of basophils in immunity shows novel functions at a cellular level through which basophils influence adaptive immunity. This review summarizes new advances in basophil biology and discusses new roles for basophils in human disease, especially in the mediation of the pathogenesis of lupus nephritis. Recently, basophils have been shown to contribute to self-reactive antibody production in systemic lupus erythematosus and may enhance pre-existing loss of B cell tolerance, suggesting that basophils, IL-4 and IgE mediate the pathogenesis of lupus nephritis by promoting the Th2 environment and activating autoreactive B cells. In addition to envisaging exciting therapeutic prospects, these novel findings open the way for the study of basophils in other autoimmune and renal diseases.
登录
查看更多内容
影响因子：
13.6
作者：
Crispín JC;Liossis SN;Kis-Toth K;Lieberman LA;Kyttaris VC;Juang YT;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
6.8
作者：
Arinobu, Yojiro;Iwasaki, Hiromi;Akashi, Koichi
通讯作者：
Akashi, Koichi
影响因子：
30.5
作者：
Hida, Shigeaki;Yamasaki, Sho;Taki, Shinsuke
通讯作者：
Taki, Shinsuke
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
14.2
作者：
ASKENASE, PW
通讯作者：
ASKENASE, PW