Multiscale nature of cell rearrangement caused by collective cell migration
Multiscale nature of cell rearrangement caused by collective cell migration
复制标题
集体细胞迁移引起的细胞重排的多尺度性质
DOI：
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
M. Milivojevic
中科院分区：
文献类型：
--
作者：
I. Pajic;M. Milivojevic
集体细胞迁移（CCM）是一种高度协调和微调的迁移模式，涉及大量生物过程，例如胚胎发生、组织修复和癌症侵袭。虽然细胞如何集体迁移的分子规则已经产生了很好的理解，集体迁移的细胞重排的影响仍然不太清楚。因此，从多尺度定量方法考虑CCM可能会产生一个强大的工具来解决CCM中细胞重排的贡献，并有助于理解这个重要但仍有争议的话题。在这项工作中，现有的文献在CCM建模在不同的尺度上给出了沿着与分类公布的实验结果，邀请实验学家测试给定的理论考虑在多细胞系统。此外，考虑了三种不同的时间和空间尺度（自由或弱连接细胞、细胞簇和不同细胞簇的碰撞前沿），并讨论了这些过程的多尺度性质，特别强调了干扰和非干扰状态。
Collective cell migration (CCM), a highly coordinated and fine-tuned migratory mode, is involved in a plethora of biological processes, such as embryogenesis, tissue repair and cancer invasion. Although a good comprehension of how cells collectively migrate by following molecular rules has been generated, the impact of cellular rearrangements on collective migration remains less understood. Thus, considering CCM from a multi-scale quantitative approach could result in a powerful tool to address the contribution of cellular rearrangements in CCM and help to understand this important but still controversial topic. In this work, a review of existing literature in CCM modeling at different scales is given along with assortment of published experimental findings, to invite experimentalists to test given theoretical considerations in multicellular systems. In addition, three different time and space scales (free or weakly connected cells, cluster of cells and collision fronts of different cells clusters) are considered and the multi-scale nature of those processes was discussed with special emphasis of jamming and unjamming states.
影响因子：
6.4
作者：
Hampel, Ulrike;Garreis, Fabian;Paulsen, Friedrich
通讯作者：
Paulsen, Friedrich
影响因子：
12.5
作者：
Bi, Dapeng;Yang, Xingbo;Manning, M. Lisa
通讯作者：
Manning, M. Lisa
影响因子：
3.7
作者：
Lange, Janina R.;Fabry, Ben
通讯作者：
Fabry, Ben