Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma
Altered topological properties of the intrinsic functional brain network in patients with right-sided unilateral hearing loss caused by acoustic neuroma
复制标题
听神经瘤引起的右侧单侧听力损失患者内在功能脑网络拓扑特性的改变
DOI：
10.1007/s11682-022-00658-1
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发表时间：
2022-04
影响因子：
3.2
通讯作者：
Wei Zhu
中科院分区：
文献类型：
--
作者：
Zhiyuan Fan;Zhen Fan;Tianming Qiu;Liuxun Hu;Yuan Shi;Yunman Xia;Xiaoyi Sun;Yingjun Liu;Sichen Li;Mingrui Xia;Wei Zhu
神经影像学研究已经发现单侧听力损失（UHL）患者特定脑区之间的功能连接改变，以及UHL侧对神经可塑性的不同影响。然而，关于UHL患者全脑功能网络的变化以及右侧UHL（RUHL）和左侧UHL（LUHL）之间是否存在拓扑组织差异的研究却知之甚少。为了解决这个问题，我们采用静息态功能磁共振成像（rs-fMRI）和图形理论的方法来研究RUHL和LUHL患者的脑功能连接体的拓扑结构改变。收集了44例UHL患者（包括22例RUHL患者和22例LUHL患者）和37例健康对照者（HC）的数据。为每个参与者构建功能性大脑网络，然后在连接和全局（例如，小世界）水平。进一步研究了脑网络拓扑结构与临床变量之间的相关性。使用基于网络的分析，我们发现了一个子网络的视觉皮层，有显着较低的连接强度与RUHL患者相比，HC。在整体水平上，所有参与者都表现出小世界结构的功能性脑网络，然而，显着较低的标准化聚类系数和小世界性观察RUHL患者比HC。此外，这些异常的网络指标被证明与RUHL患者的临床变量和认知表现相关。值得注意的是，在LUHL患者中未发现功能性脑网络的显著改变。我们的研究结果表明，RUHL（而不是LUHL）是伴随着异常的拓扑结构的功能脑连接体，从网络拓扑结构的观点表明不同的病理生理机制之间的RUHL和LUHL。
Neuroimaging studies have identified alterations in functional connectivity between specific brain regions in patients with unilateral hearing loss (UHL) and different influence of the side of UHL on neural plasticity. However, little is known about changes of whole-brain functional networks in patients with UHL and whether differences exist in topological organization between right-sided UHL (RUHL) and left-sided UHL (LUHL). To address this issue, we employed resting-state fMRI (rs-fMRI) and graph-theoretical approaches to investigate the topological alterations of brain functional connectomes in patients with RUHL and LUHL. Data from 44 patients with UHL (including 22 RUHL patients and 22 LUHL patients) and 37 healthy control subjects (HCs) were collected. Functional brain networks were constructed for each participant, following by graph-theoretical network analyses at connectional and global (e.g., small-worldness) levels. The correlations between brain network topologies and clinical variables were further studied. Using network-based analysis, we found a subnetwork in the visual cortex which had significantly lower connectivity strength in patients with RUHL as compared to HCs. At global level, all participants showed small-world architecture in functional brain networks, however, significantly lower normalized clustering coefficient and small-worldness were observed in patients with RUHL than in HCs. Moreover, these abnormal network metrics were demonstrated to be correlated with the clinical variables and cognitive performance of patients with RUHL. Notably, no significant alterations in the functional brain networks were found in patients with LUHL. Our findings demonstrate that RUHL (rather than LUHL) is accompanied with aberrant topological organization of the functional brain connectome, indicating different pathophysiological mechanisms between RUHL and LUHL from a viewpoint of network topology.
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影响因子：
3.7
作者：
Firszt JB;Reeder RM;Holden LK
通讯作者：
Holden LK
影响因子：
2.4
作者：
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