Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.
Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.
复制标题
体外谷胱甘肽对卟啉原氧化的减弱和卟啉原微量金属的逆转。
DOI:
10.1016/s0006-291x(88)80445-5
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发表时间:
1988
影响因子:
3.1
通讯作者:
Woods,JS
中科院分区:
文献类型:
--
作者:
Woods,JS
We have employed a modelinvitrosystem for iron-peroxide-catalyzed oxidation of porphyrinogens to investigate the potential role of glutathione (GSH) in trace metal-induced porphyrias. GSH strongly attenuates porphyrinogen oxidation at biologically relevant concentrations in a dose-dependent manner. Porphyrinogenic trace metals reduce the effectiveness of GSH as a porphyrinogen antioxidant, leading to significantly higher rates of porphyrinogen oxidation to porphyrins. These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures.
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影响因子:
3.8
作者:
N. Stacey;Hermann Kappus
通讯作者:
Hermann Kappus
影响因子:
3.8
作者:
J. S. Woods;B. Fowler
通讯作者:
B. Fowler
影响因子:
3.6
作者:
FOWLER, BA;WOODS, JS
通讯作者:
WOODS, JS
影响因子:
4.1
作者:
UDOM, AO;BRADY, FO
通讯作者:
BRADY, FO
影响因子:
3.8
作者:
Woods,JS;Fowler,BA
通讯作者:
Fowler,BA