Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.

Attenuation of porphyrinogen oxidation by glutathione in vitro and reversal by porphyrinogenic trace metals.
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体外谷胱甘肽对卟啉原氧化的减弱和卟啉原微量金属的逆转。

DOI:
10.1016/s0006-291x(88)80445-5
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发表时间:
1988
影响因子:
3.1
通讯作者:
Woods,JS
Woods,JS
中科院分区:
生物学4区
文献类型:
--
作者:
Woods,JS

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We have employed a modelinvitrosystem for iron-peroxide-catalyzed oxidation of porphyrinogens to investigate the potential role of glutathione (GSH) in trace metal-induced porphyrias. GSH strongly attenuates porphyrinogen oxidation at biologically relevant concentrations in a dose-dependent manner. Porphyrinogenic trace metals reduce the effectiveness of GSH as a porphyrinogen antioxidant, leading to significantly higher rates of porphyrinogen oxidation to porphyrins. These observations may, in part, underlie the etiology of porphyrinurias induced during prolonged trace metal exposures.
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