Health-related quality of life, lifestyle behaviors, and intervention preferences of survivors of childhood cancer.
Health-related quality of life, lifestyle behaviors, and intervention preferences of survivors of childhood cancer.
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DOI：
10.1007/s11764-013-0289-3
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Demark-Wahnefried W
中科院分区：
文献类型：
--
作者：
Badr H;Chandra J;Paxton RJ;Ater JL;Urbauer D;Cruz CS;Demark-Wahnefried W
儿童癌症幸存者 (CCS) 面临与健康相关的生活质量 (HRQOL) 较差和慢性健康问题的风险增加，而这两种情况都可能因不健康的生活方式行为而加剧。更清楚地了解 HRQOL、生活方式行为以及医疗和人口变量（例如诊断时的年龄/发育阶段）之间的关联，是针对该人群制定更有针对性的行为干预措施的重要一步。 170 名 CCS 完成了横断面调查问卷，这些 CCS 被诊断患有白血病、淋巴瘤、肉瘤或中枢神经系统 (CNS) 癌症，并于 1992 年至 2007 年间在综合癌症中心接受治疗。调查问卷涉及体重状况、生活方式、HRQOL 方面以及干预偏好。与较早诊断的患者、白血病或肉瘤的幸存者以及健康人群相比，青少年和青年幸存者 (AYA) 以及中枢神经系统肿瘤或淋巴瘤的幸存者在多个领域的 HRQOL 显着较差 (p<.05)。很大一部分人也未能达到国家关于膳食摄入量（39-94%）和体力活动（65%）的建议。与男性幸存者相比，女性幸存者的身体机能较差，膳食纤维、水果和蔬菜的摄入量也较少。他们还对参与饮食和运动干预表示了最强烈的兴趣。研究结果支持这样一个前提：女性、AYA 和中枢神经系统癌症或淋巴瘤幸存者是 CCS 人群中因不良饮食习惯、久坐行为和 HRQOL 较差而“面临风险”的亚群。未来的研究应侧重于开发饮食和 PA 干预措施，以改善针对这些群体的 HRQOL。更多地考虑性别的作用、发育阶段以及 CCS 面临的 HRQOL 挑战可能有助于研究人员为那些受益最大的人制定有针对性的行为干预措施。
Childhood cancer survivors (CCSs) are at increased risk for poor health-related quality of life (HRQOL) and chronic health conditions -- both of which can be exacerbated by unhealthy lifestyle behaviors. Developing a clearer understanding of the associations between HRQOL, lifestyle behaviors, and medical and demographic variables (e.g., age/developmental stage at time of diagnosis) is an important step toward developing more targeted behavioral interventions for this population. Cross-sectional questionnaires were completed by 170 CCSs who were diagnosed with leukemia, lymphoma, sarcoma, or a cancer of the central nervous system (CNS) and treated at a comprehensive cancer center between 1992 and 2007. Questionnaires addressed weight status, lifestyle behaviors, aspects of HRQOL, and intervention preferences. Adolescent and young adult survivors (AYAs) and survivors of CNS tumors or lymphoma reported significantly (p<.05) poorer HRQOL across multiple domains compared to those diagnosed at an earlier age, survivors of leukemia or sarcoma, and healthy populations. A significant proportion also failed to meet national recommendations for dietary intakes (39–94%) and physical activity (65%). Female survivors reported poorer physical functioning and consumed less dietary fiber and fruits and vegetables than did male survivors. They also expressed the strongest interest in participating in diet and exercise interventions. Findings support the premise that females, AYAs, and survivors of cancers of the CNS or lymphoma are “at risk” subgroups within the CCS population for poor dietary practices, sedentary behaviors, and poor HRQOL. Future research should focus on developing diet and PA interventions to improve HRQOL that target these groups. Greater consideration of the role of gender, developmental stage, and the HRQOL challenges facing CCSs may help researchers to develop targeted behavioral interventions for those who stand to benefit the most.
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影响因子：
6.2
作者：
Demark-Wahnefried, W;Werner, C;Rosoff, PM
通讯作者：
Rosoff, PM
影响因子：
7.1
作者：
Fogli-Cawley, Jeanene J.;Dwyer, Johanna T.;Jacques, Paul F.
通讯作者：
Jacques, Paul F.
影响因子：
45.3
作者：
Garmey, Edward G.;Liu, Qi;Oeffinger, Kevin C.
通讯作者：
Oeffinger, Kevin C.
影响因子：
45.3
作者：
Blanchard, Christopher M.;Courneya, Kerry S.;Stein, Kevin
通讯作者：
Stein, Kevin
影响因子：
3.3
作者：
Blanchard, CM;Stein, KD;Nehl, E
通讯作者：
Nehl, E