Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles.
Factors associated with monozygosity in assisted reproductive technology pregnancies and the risk of recurrence using linked cycles.
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DOI：
10.1016/j.fertnstert.2013.11.034
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发表时间：
2014-03
影响因子：
6.7
通讯作者：
Stern, Judy E.
中科院分区：
文献类型：
--
作者：
Luke, Barbara;Brown, Morton B.;Wantman, Ethan;Stern, Judy E.
为了评估与单合子(早期超声胎儿心跳数大于移植胚胎数)和后续妊娠复发风险相关的因素，使用国家ART数据库历史队列研究诊所数据，从2004至2010年间向SART CORS报告的周期中获得197,327例妊娠(包括2,824例单合子妊娠)。调整后的优势比及其95%可信区间由Logistic回归模型计算。没有单一合子的证据。在单因素分析中，排卵障碍、供体卵母细胞、GnRHa抑制、辅助孵化(AZH)和第5-6天移植增加了MZ的风险，而较高的FSH剂量(≥3,000IU)则降低了MZ的风险。在多因素分析中，GnRHa抑制、azh增加MZ的风险，ICSI和较高的FSH剂量降低MZ的风险。交互作用表明，虽然MZ对第5-6天胚胎的影响更大，但azh的影响很小，而在2-3天的胚胎中，azh的影响非常显著。在随后的ART妊娠中，只有一名女性出现了单合子复发，这与随机性是一致的。第5-6天新鲜胚胎、供体卵母细胞、GnRHa抑制、较低的FSH剂量和AZH(尤其是第2-3天胚胎)发生MZ的风险较高。
To evaluate factors associated with monozygosity (number of fetal heartbeats on early ultrasound greater than number of embryos transferred) and the risk of recurrence in subsequent pregnancies using a national ART database Historical cohort study Clinic-based data 197,327 pregnancies (including 2,824 with evidence of monozygosity) from cycles reported to SART CORS between 2004 and 2010. Adjusted odds ratios and their 95% confidence intervals were computed from logistic regression models. None Evidence of monozygosity. In the univariate analysis, the risk of MZ was increased with ovulation disorders, donor oocytes, GnRHA suppression, assisted hatching (AZH), and day 5–6 transfer, and decreased with higher FSH doses (≥3,000 IU). In the multivariate analysis, the risk of MZ was increased with GnRHA suppression, AZH, and decreased with ICSI and higher FSH dose. The interaction showed that although MZ was more likely with day 5–6 embryos, AZH had a minimal nonsignificant effect, whereas in day 2–3 embryos, AZH had a substantial significant effect. Only one woman had a recurrence of monozygosity in a subsequent ART pregnancy, which is consistent with randomness. The risk of MZ was higher with fresh day 5–6 embryos, donor oocytes, GnRHA suppression, lower FSH doses, and AZH (particularly with day 2–3 embryos).
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影响因子：
6.1
作者：
Alikani, M;Cekleniak, NA;Cohen, J
通讯作者：
Cohen, J
影响因子：
6.7
作者：
Knopman, Jaime;Krey, Lewis C.;Noyes, Nicole
通讯作者：
Noyes, Nicole
影响因子：
6.1
作者：
Delbaere, I.;Goetgeluk, S.;Temmerman, M.
通讯作者：
Temmerman, M.
DOI：
10.1023/b:jarg.0000029493.54929.be
发表时间：
2004-04-01
影响因子：
3.1
作者：
Jain, JK;Boostanfar, R;Paulson, RJ
通讯作者：
Paulson, RJ
影响因子：
105.7
作者：
Bukowski, R.;Smith, G. C. S.;D'Alton, M. E.
通讯作者：
D'Alton, M. E.