The proliferative human monocyte subpopulation contains osteoclast precursors.
The proliferative human monocyte subpopulation contains osteoclast precursors.
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DOI：
10.1186/ar2616
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发表时间：
2009
影响因子：
4.9
通讯作者：
Hamilton JA
中科院分区：
文献类型：
--
作者：
Lari R;Kitchener PD;Hamilton JA
骨吸收破骨细胞的直接前体是单核细胞/巨噬细胞系细胞。特别是在临床表现为骨质流失的情况下，破骨细胞前体在进入骨质流失的组织之前从骨髓中被动员到循环中。观察到的外周血单核细胞的异质性导致了不同单核细胞亚群可能具有特殊或限制功能的概念，包括作为破骨细胞前体。根据人外周血单核细胞的增殖程度进行分类，并在巨噬细胞集落刺激因子（M-CSF或CSF-1）和核因子- κ b配体受体激活剂（RANKL）中培养。能够增殖的单核细胞亚群比大部分单核细胞产生更多的多核、骨吸收的破骨细胞。人外周血破骨细胞前体存在于增殖单核细胞亚群中。
Immediate precursors of bone-resorbing osteoclasts are cells of the monocyte/macrophage lineage. Particularly during clinical conditions showing bone loss, it would appear that osteoclast precursors are mobilized from bone marrow into the circulation prior to entering tissues undergoing such loss. The observed heterogeneity of peripheral blood monocytes has led to the notion that different monocyte subpopulations may have special or restricted functions, including as osteoclast precursors. Human peripheral blood monocytes were sorted based upon their degree of proliferation and cultured in macrophage colony-stimulating factor (M-CSF or CSF-1) and receptor activator of nuclear factor-kappa-B ligand (RANKL). The monocyte subpopulation that is capable of proliferation gave rise to significantly more multinucleated, bone-resorbing osteoclasts than the bulk of the monocytes. Human peripheral blood osteoclast precursors reside in the proliferative monocyte subpopulation.
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影响因子：
4.9
作者：
Komano Y;Nanki T;Hayashida K;Taniguchi K;Miyasaka N
通讯作者：
Miyasaka N
DOI：
10.1002/stem.5530080503
发表时间：
1990-09-01
期刊：
INTERNATIONAL JOURNAL OF CELL CLONING
影响因子：
--
作者：
ERICKSONMILLER, CL;BRENNAN, JK;ABBOUD, CN
通讯作者：
ABBOUD, CN
影响因子：
20.3
作者：
Dai, XM;Ryan, GR;Stanley, ER
通讯作者：
Stanley, ER
影响因子：
4.8
作者：
Fujikawa, Y;Quinn, JMW;Athanasou, NA
通讯作者：
Athanasou, NA
影响因子：
15.9
作者：
Ritchlin, CT;Haas-Smith, SA;Schwarz, EM
通讯作者：
Schwarz, EM