Smoking, radiotherapy, diabetes and osteoporosis as risk factors for dental implant failure: a meta-analysis.
Smoking, radiotherapy, diabetes and osteoporosis as risk factors for dental implant failure: a meta-analysis.
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DOI：
10.1371/journal.pone.0071955
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lu E
中科院分区：
文献类型：
--
作者：
Chen H;Liu N;Xu X;Qu X;Lu E
关于吸烟、放疗、糖尿病和骨质疏松症与种植牙失败风险之间的关系，有相互矛盾的报道。我们进行了一项荟萃分析，以评估吸烟、放疗、糖尿病和骨质疏松症与牙种植失败风险之间的关系。截至2013年1月，对MEDLINE和EMBASE进行了全面研究，以确定潜在的研究。同时检索相关研究的参考文献。筛选、数据提取和质量评估独立进行，一式两份。随机效应荟萃分析用于汇总相对风险（RR）估计值和95%置信区间（CI）。在这项荟萃分析中，共确定了51项研究，其中超过40，000个牙种植体置于危险条件下。汇总的RR显示，吸烟（n = 33; RR = 1.92; 95% CI，1.67-2.21）和放疗（n = 16; RR = 2.28; 95% CI，1.49-3.51）与牙种植体失败风险之间存在直接相关性，而糖尿病（n = 5; RR = 0.90;骨质疏松对种植体失败的影响有直接影响，但无统计学意义（n = 4; RR = 1.09，95%CI，0.79-1.52）。亚组分析表明，研究设计、地理位置、随访时间、样本量或招募患者的平均年龄均无影响。吸烟和放射治疗与牙种植失败的风险增加有关。糖尿病和骨质疏松症之间的关系以及种植体失败的风险需要进一步研究。
There are conflicting reports as to the association between smoking, radiotherapy, diabetes and osteoporosis and the risk of dental implant failure. We undertook a meta-analysis to evaluate the association between smoking, radiotherapy, diabetes and osteoporosis and the risk of dental implant failure. A comprehensive research on MEDLINE and EMBASE, up to January 2013, was conducted to identify potential studies. References of relevant studies were also searched. Screening, data extraction and quality assessment were conducted independently and in duplicate. A random-effects meta-analysis was used to pool estimates of relative risks (RRs) with 95% confidence intervals (CIs). A total of 51 studies were identified in this meta-analysis, with more than 40,000 dental implants placed under risk-threatening conditions. The pooled RRs showed a direct association between smoking (n = 33; RR = 1.92; 95% CI, 1.67–2.21) and radiotherapy (n = 16; RR = 2.28; 95% CI, 1.49–3.51) and the risk of dental implant failure, whereas no inverse impact of diabetes (n = 5; RR = 0.90; 95% CI, 0.62–1.32) on the risk of dental implant failure was found. The influence of osteoporosis on the risk of dental implant failure was direct but not significant (n = 4; RR = 1.09; 95% CI, 0.79–1.52). The subgroup analysis indicated no influence of study design, geographical location, length of follow-up, sample size, or mean age of recruited patients. Smoking and radiotherapy were associated with an increased risk of dental implant failure. The relationship between diabetes and osteoporosis and the risk of implant failure warrant further study.
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影响因子：
0.9
作者：
Gaetti-Jardim, Ellen Cristina;Santiago-Junior, Joel Ferreira;Jardim Junior, Elerson Gaetti
通讯作者：
Jardim Junior, Elerson Gaetti
影响因子：
6.7
作者：
Dvorak, Gabriella;Arnhart, Christoph;Gruber, Reinhard
通讯作者：
Gruber, Reinhard
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
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作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.3
作者：
Alsaadi, Ghada;Quirynen, Marc;van Steenberghe, Daniel
通讯作者：
van Steenberghe, Daniel
DOI：
10.1111/j.1708-8208.2010.00282.x
发表时间：
2012-06-01
影响因子：
3.6
作者：
Cosyn, Jan;Vandenbulcke, Edward;De Bruyn, Hugo
通讯作者：
De Bruyn, Hugo