Serum monocyte chemoattractant protein-1 in pancreatic cancer.
Serum monocyte chemoattractant protein-1 in pancreatic cancer.
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DOI：
10.1155/2011/518394
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发表时间：
2011
影响因子：
--
通讯作者：
Arafat HA
中科院分区：
文献类型：
--
作者：
Sullivan J;Gong Q;Hyslop T;Lavu H;Chipitsyna G;Yeo CJ;Arafat HA
Background/Aims. Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients. Methods. ELISA was used to analyze MCP-1 serum levels in PDA (n = 62) and intraductal papillary mucinous neoplasms (IPMN) (n = 27). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters. Results. Log MCP-1 values were significantly (P < 0.05) elevated in patients with BMI ≥ 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age. Conclusion. MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.
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影响因子：
8.8
作者：
Hefler, L;Tempfer, C;Heinze, G;Mayerhofer, K;Breitenecker, G;Leodolter, S;Reinthaller, A;Kainz, C
通讯作者：
Kainz, C
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Giroir, BP
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通讯作者：
Pirags, Valdis
影响因子：
4.9
作者：
Kim, C-S;Park, H-S;Yu, R.
通讯作者：
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