A gut microbial factor modulates locomotor behaviour in Drosophila.
A gut microbial factor modulates locomotor behaviour in Drosophila.
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DOI：
10.1038/s41586-018-0634-9
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发表时间：
2018-11
期刊：
影响因子：
64.8
通讯作者：
Mazmanian SK
中科院分区：
文献类型：
--
作者：
Schretter CE;Vielmetter J;Bartos I;Marka Z;Marka S;Argade S;Mazmanian SK
While research into the biology of animal behaviour has primarily focused on the central nervous system, cues from peripheral tissues and the environment have been implicated in brain development and function. There is emerging evidence that bidirectional communication between the gut and the brain affects behaviours including anxiety, cognition, nociception and social interaction, , , , , , , –. Coordinated locomotor behaviour is critical for the survival and propagation of animals, and is regulated by internal and external sensory inputs,. However, little is known about how the gut microbiome influences host locomotion, or the molecular and cellular mechanisms involved. Here we report that germ-free status or antibiotic treatment results in hyperactive locomotor behaviour in the fruit flyDrosophila melanogaster. Increased walking speed and daily activity in the absence of a gut microbiome are rescued by mono-colonization with specific bacteria, including the fly commensalLactobacillus brevis. The bacterial enzyme xylose isomerase fromL. brevisrecapitulates the locomotor effects of microbial colonization by modulating sugar metabolism in flies. Notably, thermogenetic activation of octopaminergic neurons or exogenous administration of octopamine, the invertebrate counterpart of noradrenaline, abrogates the effects of xylose isomerase onDrosophilalocomotion. These findings reveal a previously unappreciated role for the gut microbiome in modulating locomotion, and identify octopaminergic neurons as mediators of peripheral microbial cues that regulate motor behaviour in animals.
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影响因子：
9.8
作者：
Leitão-Gonçalves R;Carvalho-Santos Z;Francisco AP;Fioreze GT;Anjos M;Baltazar C;Elias AP;Itskov PM;Piper MDW;Ribeiro C
通讯作者：
Ribeiro C
影响因子：
3.3
作者：
Chen, Audrey;Ng, Fanny;Krantz, David E.
通讯作者：
Krantz, David E.
大肠杆菌K-12的构造框架，单基因敲除突变体：Keio Collection。
影响因子：
9.9
作者：
通讯作者：
--
影响因子：
29
作者：
Breton, Jonathan;Tennoune, Naouel;Fetissov, Serguei O.
通讯作者：
Fetissov, Serguei O.
影响因子：
5.3
作者：
Brembs, Bjoern;Christiansen, Frauke;Duch, Carsten
通讯作者：
Duch, Carsten