Correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery
Correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery
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慢性鼻窦炎合并鼻息肉患者鼻内镜手术后组织嗜酸性粒细胞计数与化学感觉功能的相关性
DOI：
10.1007/s00405-019-05413-9
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
魏永祥
中科院分区：
文献类型：
--
作者：
张丽川;胡春华;孙智甫;韩鹏飞;韩星雨;孙海丽;武大伟;吕倩雯;闫晓光;于玮;Thomas Hummel;魏永祥
目的探讨慢性鼻窦炎鼻息肉(CRSwNP)患者鼻内窥镜手术(ESS)后组织嗜酸性粒细胞计数与化学感觉功能的相关性。记录视觉模拟评分和Lund-Kennedy内窥镜评分。对筛窦粘膜进行活检并进行评估。用Sniffin氏棒和化学感觉事件相关电位(CSERP)测定化学感觉功能。在调整混杂因素后，采用Spearman相关和偏相关分析化学感觉功能与组织嗜酸性粒细胞计数的相关性。将喷嚏评分与无水乙醇刺激的CSERP进行Kendall tau-b相关分析。术后组织嗜酸性粒细胞计数与嗅觉阈值(T)评分(偏相关系数r= − 0.460，p= 0.012)、嗅觉诱发电位峰值潜伏期(N1：Partialr= 0.471，p= 0.010；P2：Partialr= 0.487，p= 0.007)和混合嗅觉-三叉神经(N1：Partialr= − 0.516，p= 0.008；P2：Partialr= − 0.590，p= 0.002)相关。打喷嚏评分与EAL的N1潜伏期呈正相关(Kendall‘s tau-b − =0.40，p= 0.005)。结论术后组织嗜酸性粒细胞增多与术后嗅觉障碍显著相关。此外，通过T评分测量的嗅觉与炎症相关性嗅觉障碍的嗅觉事件相关电位潜伏期相关。三叉神经敏感度似乎也与组织嗜酸性粒细胞增多有关，这表明粘膜炎症可以影响鼻子的两个感觉系统。
PurposeTo investigate the correlation of tissue eosinophil count and chemosensory functions in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS).MethodsThis was a cross-sectional study including 40 patients with a history of ESS for CRSwNP recruited consecutively. Visual analog scale score and the Lund–Kennedy endoscopic score were recorded. Biopsies of the ethmoidal sinus mucosal were performed and evaluated. Chemosensory functions were measured by Sniffin’ Sticks and chemosensory event-related potentials (CSERP). The associations between chemosensory functions and tissue eosinophil count were analyzed using Spearman correlation and partial correlation after adjusting the confounding factors. Kendall’s tau-b correlation was performed between sneezing score and CSERP with ethyl alcohol (EAL) stimulation.ResultsOlfactory and trigeminal nerve function was successfully evaluated using CSERP. Postoperative tissue eosinophil count was correlated with threshold (T) score (partial correlation coefficientr= − 0.460,p= 0.012) and CSERP peak latency for olfactory (N1: partialr= 0.471,p= 0.010; P2: partialr= 0.487,p= 0.007) and mixed olfactory–trigeminal (N1: partialr= − 0.516,p= 0.008; P2: partialr= − 0.590,p= 0.002). There were also correlations between T score and N1 latency with phenyl ethyl alcohol (PEA) (partialr= − 0.560,p< 0.001), between sneezing score and N1 latency with EAL (Kendall’s tau-b = − 0.40,p= 0.005).ConclusionsPostoperative tissue eosinophilia is significantly associated with postoperative olfactory disorders as assessed by Sniffin’ Sticks and CSERP peak latency. Furthermore, olfaction as measured by T score correlates with olfactory ERP latency in inflammation-associated olfactory dysfunction. Trigeminal sensitivity also appears to relate to tissue eosinophilia, indicating mucosal inflammation can affect both sensory systems in the nose.
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DOI：
10.1002/lary.27112
发表时间：
2018-09
期刊：
The Laryngoscope
影响因子：
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作者：
Wu J;Chandra RK;Li P;Hull BP;Turner JH
通讯作者：
Turner JH
影响因子：
6.4
作者：
Levy, Joshua M.;Mace, Jess C.;Sansoni, E. Ritter;Soler, Zachary M.;Smith, Timothy L.
通讯作者：
Smith, Timothy L.
影响因子：
17.1
作者：
Drake MG;Scott GD;Blum ED;Lebold KM;Nie Z;Lee JJ;Fryer AD;Costello RW;Jacoby DB
通讯作者：
Jacoby DB
DOI：
10.1016/j.jaip.2017.09.020
发表时间：
2017-10
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Dawei Wu;B. Bleier;Lun Li;X. Zhan;Lichuan Zhang;Qian-wen Lv;Jianting Wang;Yongxiang Wei
通讯作者：
Dawei Wu;B. Bleier;Lun Li;X. Zhan;Lichuan Zhang;Qian-wen Lv;Jianting Wang;Yongxiang Wei
影响因子：
--
作者：
Zdeněk Knížek;J. Vodička;Pavlína Brothánková;H. Shejbalová
通讯作者：
Zdeněk Knížek;J. Vodička;Pavlína Brothánková;H. Shejbalová