Olfactory and middle meatal cytokine levels correlate with olfactory function in chronic rhinosinusitis.
Olfactory and middle meatal cytokine levels correlate with olfactory function in chronic rhinosinusitis.
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DOI：
10.1002/lary.27112
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Turner JH
中科院分区：
文献类型：
--
作者：
Wu J;Chandra RK;Li P;Hull BP;Turner JH
慢性鼻窦炎（CRS）相关嗅觉丧失的病因尚不清楚，但可能是由于嗅觉上皮的炎症变化导致信号传导功能障碍或嗅觉神经元丧失。几种促炎细胞因子与 CRS 相关，但它们在嗅裂微环境中的表达以及与嗅觉功能的关系尚不清楚。 NA 粘液采集自 31 名不伴有鼻息肉的 CRS（CRSsNP）受试者、36 名患有鼻息肉的 CRS（CRSwNP）受试者和 12 名健康对照者的嗅裂和中道。使用经过验证的气味识别测试 (SIT) 评估嗅觉功能。使用多重流式细胞珠测定评估 14 种细胞因子/趋化因子（IL-1β、IL-2、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IL-12、IL-13、IL-17A、TNF-α、Eotaxin、RANTES）的位点特异性水平，并与 SIT 评分相关。对于除一种测量的炎症介质外的所有炎症介质，嗅裂中的粘液细胞因子水平与中鼻道中的水平呈强或中度相关。 SIT 评分与 IL-2 (p=0.006)、IL-5 (p<0.0001)、IL-6 (p=0.0009)、IL-10 (p<0.0001) 和 IL-13 (p<0.0001) 水平呈负相关，其显着性很大程度上由 CRSwNP 患者驱动。嗅裂内的炎症微环境反映了中鼻道内的炎症微环境。嗅裂粘液中 IL-2、IL-5、IL-6、IL-10 和 IL-13 水平升高与 CRS 患者嗅觉识别评分降低相关。特定嗅觉粘液细胞因子水平的改变可能会对嗅觉神经元功能和周转产生有害影响。
The etiology of chronic rhinosinusitis (CRS)-associated olfactory loss is unclear, but may result from inflammatory changes in the olfactory epithelium that result in signaling dysfunction or loss of olfactory neurons. Several pro-inflammatory cytokines have been associated with CRS but their expression within the olfactory cleft microenvironment and association with olfactory function is unknown. NA Mucus was collected from the olfactory cleft and middle meatus of 31 CRS without nasal polyp (CRSsNP) subjects, 36 CRS with nasal polyps (CRSwNP) subjects, and 12 healthy controls. Olfactory function was assessed using the validated Smell Identification Test (SIT). Site-specific levels of 14 cytokines/chemokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17A, TNF-α, Eotaxin, RANTES) were assessed using a multiplex flow cytometric bead assay and correlated with SIT scores. Mucus cytokine levels in the olfactory cleft were strongly or moderately correlated with levels in the middle meatus for all but one measured inflammatory mediators. SIT scores were inversely correlated with levels of IL-2 (p=0.006), IL-5 (p<0.0001), IL-6 (p=0.0009), IL-10 (p<0.0001), and IL-13 (p<0.0001), with significance largely driven by CRSwNP patients. The inflammatory microenvironment within the olfactory cleft mirrors that within the middle meatus. Elevated levels of IL-2, IL-5, IL-6, IL-10, and IL-13 in olfactory cleft mucus are associated with reduced olfactory identification scores in CRS patients. Altered levels of select olfactory mucus cytokines could potentially have deleterious effects on olfactory neuron function and turnover.
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影响因子：
3.5
作者：
Kanekar, Shami;Gandham, Mahendra;Lucero, Mary T.
通讯作者：
Lucero, Mary T.
影响因子：
2.6
作者：
Rudmik, Luke;Soler, Zachary M.;Mace, Jess C.;Schlosser, Rodney J.;Smith, Timothy L.
通讯作者：
Smith, Timothy L.
影响因子：
7.2
作者：
Konstantinidis, Iordanis;Witt, Martin;Gudziol, Volker
通讯作者：
Gudziol, Volker
DOI：
10.1186/s13223-016-0123-3
发表时间：
2016
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
König K;Klemens C;Haack M;Nicoló MS;Becker S;Kramer MF;Gröger M
通讯作者：
Gröger M
DOI：
10.4049/jimmunol.182.3.1404
发表时间：
2009-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kelly EA;Koziol-White CJ;Clay KJ;Liu LY;Bates ME;Bertics PJ;Jarjour NN
通讯作者：
Jarjour NN