Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups.
Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups.
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具有大体积芳香族端基的肽共轭物的自组装、生物活性和纳米材料应用。
DOI：
10.1021/acsabm.2c01041
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发表时间：
2023-02-20
影响因子：
4.7
通讯作者：
Hamley IW
中科院分区：
文献类型：
--
作者：
Hamley IW
本文综述了末端含有大体积芳香取代基的肽缀合物的自组装及其结构和功能性质，并着重介绍了其生物活性。末端部分包括Fmoc [芴基甲氧基羰基]、萘、芘、萘二酰亚胺、萘或芘的二酰亚胺等。除了短肽之间的氢键、静电和其他力之外，这些还由于π堆积和疏水相互作用而为自组装提供驱动力。这些相互作用的平衡导致自组装的倾向，甚至对于与单个氨基酸的缀合物也是如此。杂化分子通常形成由β-折叠原纤维网络构建的水凝胶。这些作为生物材料的特性，以支持细胞培养，或在分子的发展，可以组装在细胞中（响应细胞酶，或以其他方式）与一系列迷人的生物活性，如抗癌或抗菌活性，突出显示。此外，还讨论了水凝胶作为缓释药物传递系统和在催化等方面的应用。取代基的芳族性质也提供了多样性的有趣的光电性能，已在文献中证明，并概述了这一点。还讨论了共组装和酶指导的自组装，使肽纳米结构的精确调谐和（刺激响应）功能化。
The self-assembly and structural and functional properties of peptide conjugates containing bulky terminal aromatic substituents are reviewed with a particular focus on bioactivity. Terminal moieties include Fmoc [fluorenylmethyloxycarbonyl], naphthalene, pyrene, naproxen, diimides of naphthalene or pyrene, and others. These provide a driving force for self-assembly due to π-stacking and hydrophobic interactions, in addition to the hydrogen bonding, electrostatic, and other forces between short peptides. The balance of these interactions leads to a propensity to self-assembly, even for conjugates to single amino acids. The hybrid molecules often form hydrogels built from a network of β-sheet fibrils. The properties of these as biomaterials to support cell culture, or in the development of molecules that can assemble in cells (in response to cellular enzymes, or otherwise) with a range of fascinating bioactivities such as anticancer or antimicrobial activity, are highlighted. In addition, applications of hydrogels as slow-release drug delivery systems and in catalysis and other applications are discussed. The aromatic nature of the substituents also provides a diversity of interesting optoelectronic properties that have been demonstrated in the literature, and an overview of this is also provided. Also discussed are coassembly and enzyme-instructed self-assembly which enable precise tuning and (stimulus-responsive) functionalization of peptide nanostructures.
影响因子：
4.7
作者：
Shi J;Du X;Yuan D;Haburcak R;Zhou N;Xu B
通讯作者：
Xu B
DOI：
10.1039/c3cc48832b
发表时间：
2014-03-14
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Kuang Y;Gao Y;Shi J;Li J;Xu B
通讯作者：
Xu B
影响因子：
3.4
作者：
Nguyen MM;Eckes KM;Suggs LJ
通讯作者：
Suggs LJ